Evidence map›Paper›PMID 29728743›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2018

The potential European genetic predisposition for non-contact anterior cruciate ligament injury.

Diego Costa Astur, Edilson Andrade, Gustavo Gonçalves Arliani, Pedro Debieux, Leonor Casilla Loyola, Sidney Emanuel Batista Dos Santos, Rommel Mario Rodriguez Burbano, Mariana Ferreira Leal, Moises Cohen

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In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Cruciate ligament healing and injury prevention in the age of regenerative medicine and technostress: homeostasis revisited.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Diego Costa AsturCentro de Traumatologia do Esporte, Orthopaedic Surgeon from Universidade Federal de São Paulo, Av Pacaembu 1024, São Paulo, SP, 01234-000, Brazil. mcastur@yahoo.com.
Edilson AndradeCentro de Traumatologia do Esporte, Orthopaedic Surgeon from Universidade Federal de São Paulo, Av Pacaembu 1024, São Paulo, SP, 01234-000, Brazil.
Gustavo Gonçalves ArlianiCentro de Traumatologia do Esporte, Orthopaedic Surgeon from Universidade Federal de São Paulo, Av Pacaembu 1024, São Paulo, SP, 01234-000, Brazil.
Pedro DebieuxCentro de Traumatologia do Esporte, Orthopaedic Surgeon from Universidade Federal de São Paulo, Av Pacaembu 1024, São Paulo, SP, 01234-000, Brazil.
Leonor Casilla LoyolaCentro de Traumatologia do Esporte, Orthopaedic Surgeon from Universidade Federal de São Paulo, Av Pacaembu 1024, São Paulo, SP, 01234-000, Brazil.
Sidney Emanuel Batista Dos SantosLaboratório de Genética Humana e Médica, Deparatamento de Patologia, Universidade Federal do Pará, Belém, Brazil.
Rommel Mario Rodriguez BurbanoLaboratório de Citogenética Humana, Universidade Federal do Pará, Belém, Brazil.
Mariana Ferreira LealDepartment of Genetics and Othopaedics and Traumatology, Universidade Federal de São Paulo, São Paulo, Brazil.
Moises CohenCentro de Traumatologia do Esporte, Orthopaedic Surgeon from Universidade Federal de São Paulo, Av Pacaembu 1024, São Paulo, SP, 01234-000, Brazil.
Universidade Federal de São Paulo · BRUniversidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious research has provided evidence of a hereditary predisposition for anterior cruciate ligament (ACL) injury. The purpose of this study was to evaluate the association between ancestral population genetics and risk of non-contact ACL injuries.

methodsBlood samples were collected from 177 individuals with a history of non-contact ACL injury and 556 non-injured control individuals for analysis of the genetic material through the use of a panel of 48 INDELs ancestry genetic markers from three ancestral origins.

resultsAmong patients with non-contact ACL injury, 82% were male and 18% were female. In the control group, 78% were male, and 22% were female. The mean age of the non-contact ACL injury group was 31.7 years (± 10.2), and the control group was 33.8 years (± 13.2). The individual genetic contribution from INDELs of each ancestral origin varied considerably: ranging between 1.5-94.8% contribution for INDELs of African origin (mean of 21.4% of INDELs); between 2 and 96.1% contribution for INDELs of European origin (mean of 66.7% of INDELs); and between 1.3-96.4% contribution for INDELs of Amerindian origin (mean of 11.7% of INDELs). When comparing paired subjects from the non-contact ACL and control groups, the genetic analysis showed that the European ancestry score was higher in the non-contact ACL group than control group (0.70 ± 0.21 vs 0.63 ± 0.22 respectively, p < 0.001), whereas African ancestry scores (ACL group 0.18 ± 0.18 vs control group 0.24 ± 0.21, p < 0.001) and Amerindian ancestry scores (ACL group 0.11 ± 0.09 vs control group 0.12 ± 0.10, n.s.) were lower among the non-contact ACL group than in controls.

conclusionEuropean INDELs markers were found to represent a potential genetic predisposition for non-contact ACL injuries when compared to African and Amerindian INDELs. This study has the potential to correlate a measurable and distinct genetic marker with risk of a non-contact ACL injury. Thus, it increases knowledge base and volume of molecular and genetical factors associated with this pathology. Furthermore, this study provides guidance and evidence for the development of genetic risk-screening panels for non-contact ACL injury. LEVEL OF EVIDENCE: Level III Diagnostic Study.

Indexed as

Genetic Predisposition to DiseaseAdultAnterior Cruciate Ligament InjuriesCase-Control StudiesFemaleGene FrequencyGenotypeHumansINDEL MutationMalePolymerase Chain ReactionRacial Groups

Identifiers

PMID29728743
OpenAlexW2799794804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.