Evidence map›Paper›PMID 29728713›Full record

ArticleCellular and molecular life sciences : CMLS2018

Proliferation of hippocampal progenitors relies on p27-dependent regulation of Cdk6 kinase activity.

Nicolas Caron, Emmanuelle C Genin, Quentin Marlier, Sébastien Verteneuil, Pierre Beukelaers, Laurence Morel, Miaofen G Hu, Philip W Hinds, Laurent Nguyen, Renaud Vandenbosch and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Nicolas CaronLaboratory of Developmental Neurobiology, GIGA-Neurosciences, Quartier Hôpital, University of Liège, Avenue Hippocrate 15, B36 +1, 4000, Liège, Belgium.
Emmanuelle C GeninLaboratory of Developmental Neurobiology, GIGA-Neurosciences, Quartier Hôpital, University of Liège, Avenue Hippocrate 15, B36 +1, 4000, Liège, Belgium.
Quentin MarlierLaboratory of Developmental Neurobiology, GIGA-Neurosciences, Quartier Hôpital, University of Liège, Avenue Hippocrate 15, B36 +1, 4000, Liège, Belgium.
Sébastien VerteneuilLaboratory of Developmental Neurobiology, GIGA-Neurosciences, Quartier Hôpital, University of Liège, Avenue Hippocrate 15, B36 +1, 4000, Liège, Belgium.
Pierre BeukelaersLaboratory of Developmental Neurobiology, GIGA-Neurosciences, Quartier Hôpital, University of Liège, Avenue Hippocrate 15, B36 +1, 4000, Liège, Belgium.
Laurence MorelDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Miaofen G HuMolecular Oncology Research Institute, Tufts Medical Center, 75 Kneeland Street, Boston, MA, USA.
Philip W HindsMolecular Oncology Research Institute, Tufts Medical Center, 75 Kneeland Street, Boston, MA, USA.
Laurent NguyenMolecular Regulation of Neurogenesis, GIGA-Neurosciences, University of Liège, Liège, Belgium.
Renaud VandenboschLaboratory of Developmental Neurobiology, GIGA-Neurosciences, Quartier Hôpital, University of Liège, Avenue Hippocrate 15, B36 +1, 4000, Liège, Belgium.
Brigitte MalgrangeLaboratory of Developmental Neurobiology, GIGA-Neurosciences, Quartier Hôpital, University of Liège, Avenue Hippocrate 15, B36 +1, 4000, Liège, Belgium. bmalgrange@ulg.ac.be.ORCID http://orcid.org/0000-0002-8957-2528
University of Liège · BETufts Medical Center · USTufts University · USUniversity of Florida · US

Funding

Belspo P7/07
6 · The paper itself

Abstract

Neural stem cells give rise to granule dentate neurons throughout life in the hippocampus. Upon activation, these stem cells generate fast proliferating progenitors that complete several rounds of divisions before differentiating into neurons. Although the mechanisms regulating the activation of stem cells have been intensively studied, little attention has been given so far to the intrinsic machinery allowing the expansion of the progenitor pool. The cell cycle protein Cdk6 positively regulates the proliferation of hippocampal progenitors, but the mechanism involved remains elusive. Whereas Cdk6 functions primarily as a cell cycle kinase, it can also act as transcriptional regulator in cancer cells and hematopoietic stem cells. Using mouse genetics, we show here that the function of Cdk6 in hippocampal neurogenesis relies specifically on its kinase activity. The present study also reveals a specific regulatory mechanism for Cdk6 in hippocampal progenitors. In contrast to the classical model of the cell cycle, we observe that the Cip/Kip family member p27, rather than the Ink4 family, negatively regulates Cdk6 in the adult hippocampus. Altogether, our data uncover a unique, cell type-specific regulatory mechanism controlling the expansion of hippocampal progenitors, where Cdk6 kinase activity is modulated by p27.

Indexed as

Cell ProliferationAnimalsCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p18Cyclin-Dependent Kinase Inhibitor p27Dentate GyrusHippocampusMiceMice, Inbred C57BLMice, KnockoutMutagenesis, Site-DirectedNeural Stem CellsNeurogenesisCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p18Cyclin-Dependent Kinase Inhibitor p27Adult neurogenesisCdk inhibitorsCdksCell cycleDentate gyrus

Identifiers

PMID29728713
PMCPMC11105564
OpenAlexW2802858329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.