Evidence map›Paper›PMID 29728642›Full record

ArticleMucosal immunology2018

A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis.

Jonathan C Jeschke, Christopher G Mayne, Jennifer Ziegelbauer, Christopher L DeCiantis, Selina Singh, Suresh N Kumar, Mariko Suchi, Yoichiro Iwakura, William R Drobyski, Nita H Salzman and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jonathan C JeschkeDepartment of Pediatrics, Section of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Christopher G MayneDepartment of Pediatrics, Section of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Jennifer ZiegelbauerDepartment of Pediatrics, Section of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Christopher L DeCiantisDepartment of Pediatrics, Section of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Selina SinghDepartment of Pediatrics, Section of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Suresh N KumarDepartment of Pathology, Division of Pediatric Pathology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Mariko SuchiDepartment of Pathology, Division of Pediatric Pathology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Yoichiro IwakuraResearch Institute for Biomedical Sciences, Tokyo University of Science, Chiba, 278-0022, Japan.
William R DrobyskiDepartment of Medicine, Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Nita H SalzmanDepartment of Pediatrics, Section of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Calvin B WilliamsDepartment of Pediatrics, Section of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. cwilliam@mcw.edu.
Medical College of Wisconsin · USTokyo University of Science · JPViterbo University · US

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Mechanisms of Disease Pathogenesis in Regulatory T cell DeficiencyR01AI085090 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHATILA, TALAL AMINE, WILLIAMS, CALVIN B · 2010 to 2020
$3.9M
CM F32 12-08-10 ResubmissionF32AI092977 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MAYNE, CHRISTOPHER GARY · 2011 to 2013
$170k
NIAID NIH HHS F32 AI092977NIAID NIH HHS R01 AI085090NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

Homeostasis in the ileum, which is commonly disrupted in patients with Crohn's disease, involves ongoing immune responses. To study how homeostatic processes of the ileum impact CD4

Indexed as

AnimalsColitisCrohn DiseaseDisease Models, AnimalHumansHyperplasiaIleumInterferon-gammaInterleukin-17MiceMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaSelf ToleranceTh17 CellsTh1 CellsInterferon-gammaInterleukin-17Receptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID29728642
PMCPMC6571016
OpenAlexW2799986722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.