ArticleScientific reports2018
Near-Infrared Fluorescence Imaging Directly Visualizes Lymphatic Drainage Pathways and Connections between Superficial and Deep Lymphatic Systems in the Mouse Hindlimb.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Lymphatic topology reveals a novel intranodal lympho-venous shunt.The Journal of pathology · 2026Article
- Lymphatic‑specific magnetic resonance lymphangiography biomarkers for grading lymphedema in animal models.Scientific reports · 2026Article
- Lymphatic Vessels are Involved in Monosodium Urate Clearance and Resolution of Gouty Inflammation in Mice.Journal of inflammation research · 2026Article
- A novel method for targeting lymphatic vessel imaging: methylene blue nanoparticle integrated with dissolvable microneedles.Burns & trauma · 2026Article
- Exogenous IFN-α delivered as an intranasal adjunct to systemic vaccination directs vaccine-specific T-cell responses to the upper respiratory tract.Frontiers in immunology · 2026Article
- Reconstruction of the lymphatic system by transplantation of a centrifuge-based bioengineered lymphatic tissue.Nature communications · 2025Article
- [Research progress on rodent models of secondary lymphedema].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Selectivity of bovine interleukin-2 mutein stimulation on bovine peripheral blood mononuclear cells.The Journal of veterinary medical science · 2025Article
- Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs.Nature communications · 2025Article
- A novel therapy for fracture healing by increasing lymphatic drainage.Journal of orthopaedic translation · 2024Article
- Establishment of a Simple, Reproducible, and Long-lasting Hind Limb Animal Model of Lymphedema.Plastic and reconstructive surgery. Global open · 2023Article
- Article
- Article
- Long-Duration and Non-Invasive Photoacoustic Imaging of Multiple Anatomical Structures in a Live Mouse Using a Single Contrast Agent.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Deep-skin multiphoton microscopy of lymphatic vessels excited at the 1700-nm window in vivo.Biomedical optics express · 2021Article
- Recent Advances in Fluorescence Imaging of Pulmonary Fibrosis in Animal Models.Frontiers in molecular biosciences · 2021Review
- Comparison of normal hindlimb lymphatic systems in rats with detours present after lymphatic flow blockage.PloS one · 2021Article
- Pre-collecting lymphatic vessels form detours following obstruction of lymphatic flow and function as collecting lymphatic vessels.PloS one · 2020Article
- Arterial Lymphatics in Atherosclerosis: Old Questions, New Insights, and Remaining Challenges.Journal of clinical medicine · 2019Review
- Efficacy of Neonatal Porcine Bone Marrow-Derived Mesenchymal Stem Cell Xenotransplantation for the Therapy of Hind Limb Lymphedema in Mice.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since lymphedema rarely develops in the mouse hindlimb, the underlying mechanisms remain unclear. We herein investigated the resolution of chronic hindlimb lymphedema in mice using a Near-Infrared Fluorescence (NIRF) imaging system. Nineteen 7-28-week-old BALB/c male and female mice were injected with two dyes for lymphography and dissection. Lymphadenectomy was performed on six male mice to completely obstruct lymph flow in the hindlimb. Edematous changes in both hindlimbs were compared until 60 days after surgery. The NIRF imaging system detected three lymphatic collecting systems in the mouse hindlimb: superficial lateral, superficial medial, and deep medial. It also showed connections between the superficial and deep lymphatic systems in the inguinal region. Lymphadenectomy of the iliac, inguinal, and popliteal lymph nodes caused edematous changes. However, lymph flow in these operated areas restarted within 60 days and the severity of lymphedema appeared to be low. NIRF imaging showed that the deep medial system and a connection between the superficial and deep lymphatic systems in the inguinal region drain lymph from the hindlimb. This is the one reasons why lymphedema does not develop in the mouse hindlimb. The stable obstruction of lymph flow in these three systems is desired to develop chronic lymphedema.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.