Evidence map›Paper›PMID 29728456›Full record

ArticleThe Journal of biological chemistry2018

A bipartite periplasmic receptor-diguanylate cyclase pair (XAC2383-XAC2382) in the bacterium

Raphael D Teixeira, Cristiane R Guzzo, Santiago Justo Arévalo, Maxuel O Andrade, Josielle Abrahão, Robson F de Souza, Chuck S Farah

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Xylose Isomerase Depletion Enhances Virulence ofInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Raphael D TeixeiraFrom the Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000.
Cristiane R Guzzothe Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-900, and.
Santiago Justo ArévaloFrom the Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000.
Maxuel O AndradeFrom the Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000.
Josielle Abrahãothe Departamento de Química Orgânica, Instituto de Química, Universidade de Campinas, Campinas, São Paulo 13083-970, Brazil.
Robson F de Souzathe Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-900, and.
Chuck S FarahFrom the Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, chsfarah@iq.usp.br.ORCID 0000-0003-3110-6302
Universidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The second messenger cyclic diguanylate monophosphate (c-di-GMP) is a central regulator of bacterial lifestyle, controlling several behaviors, including the switch between sessile and motile states. The c-di-GMP levels are controlled by the interplay between diguanylate cyclases (DGCs) and phosphodiesterases, which synthesize and hydrolyze this second messenger, respectively. These enzymes often contain additional domains that regulate activity via binding of small molecules, covalent modification, or protein-protein interactions. A major challenge remains to understand how DGC activity is regulated by these additional domains or interaction partners in specific signaling pathways. Here, we identified a pair of co-transcribed genes (

Indexed as

Amino Acid SequenceBacterial ProteinsCell MovementCrystallography, X-RayCyclic GMPEscherichia coli ProteinsMutationPeriplasmPhosphorus-Oxygen LyasesProtein ConformationProtein Interaction Domains and MotifsSequence HomologyXanthomonasBacterial ProteinsCyclic GMPdiguanylate cyclaseEscherichia coli ProteinsPhosphorus-Oxygen Lyasesbacterial signal transductioncell motilitycyclic di-GMP (c-di-GMP)phytopathogenplant pathogenreceptorstructural biologyXanthomonas

Identifiers

PMID29728456
PMCPMC6036220
OpenAlexW2801419111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.