Trial reportBlood2018
B-cell differentiation and IL-21 response in
Registry-linked trialOpen access · bronzeAbstract readClinical Trial
In one paragraph
Trial report in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01346150 (A Retrospective and Cross-Sectional Analysis of Patients Treated for SCID Since January 1,1968), which is not on this map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Retrospective and Cross-Sectional Analysis of Patients Treated for SCID Since January 1,1968 (RDCRN PIDTC-6902)
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Posttransplant B cell Development and Function in Patients with B cell Positive SCID Caused by Pathogenic Variants in IL2RG and JAK3.Journal of clinical immunology · 2026Article
- IL2RG-related immunodeficiencies: from SCID to atypical presentations.Frontiers in immunology · 2026Review
- IL-2RG as a possible immunotherapeutic target in CRC predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p.Journal of translational medicine · 2024Article
- Correcting inborn errors of immunity: From viral mediated gene addition to gene editing.Seminars in immunology · 2023Review
- Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation.The Journal of allergy and clinical immunology · 2023Article
- Combination of Synonymous and Missense Mutations inHuman mutation · 2023Article
- B-Cell Immune Reconstitution with Mixed Chimerism After Hematopoietic Cell Transplantation in a Patient with Severe Combined Immunodeficiency.Journal of clinical immunology · 2022Article
- T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation.Journal of clinical immunology · 2022Article
- Article
- SCID newborn screening: What we've learned.The Journal of allergy and clinical immunology · 2021Review
- Case Report: A Novel IL2RG Frame-Restoring Rescue Mutation Mimics Early T Cell Engraftment Following Haploidentical Hematopoietic Stem Cell Transplantation in a Patient With X-SCID.Frontiers in immunology · 2021Article
- Induced Pluripotent Stem Cell Meets Severe Combined Immunodeficiency.Cell journal · 2020Review
- Gene therapy for severe combined immunodeficiencies and beyond.The Journal of experimental medicine · 2020Review
- Regulation of the germinal center and humoral immunity by interleukin-21.The Journal of experimental medicine · 2020Review
- Immune Reconstitution After Gene Therapy Approaches in Patients With X-Linked Severe Combined Immunodeficiency Disease.Frontiers in immunology · 2020Review
- Chimerism in the Realm of Hematopoietic Stem Cell Transplantation for Non-malignant Disorders-A Perspective.Frontiers in immunology · 2020Article
- Intact B-Cell Signaling and Function With Host B-Cells 47 Years After Transplantation for X-SCID.Frontiers in immunology · 2020Article
- Treatment of primary immunodeficiency with allogeneic transplant and gene therapy.Hematology. American Society of Hematology. Education Program · 2019Review
- Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients.JCI insight · 2019Article
- Hematopoietic Stem Cell Transplantation in Primary Immunodeficiency Diseases: Current Status and Future Perspectives.Frontiers in pediatrics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 15 institutions in 4 countries.
Alexandra M MiggelbrinkDivision of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.
Brent R LoganDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
Rebecca H BuckleyDepartment of Pediatrics and.
Roberta E ParrottDepartment of Pediatrics and.
Christopher C DvorakDivision of Allergy/Immunology/Blood & Marrow Transplantation, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Neena KapoorDivision of Hematology, Oncology, and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA.
Hisham Abdel-AzimDivision of Hematology, Oncology, and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA.
Susan E ProckopBone Marrow Transplant Program, Memorial Sloan Kettering Cancer Center, New York, NY.
David ShyrDivision of Hematology, Primary Children's Hospital, University of Utah/Huntsman Cancer Institute, Salt Lake City, UT.
Hélène DecaluweDepartment of Pediatrics, University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada.
Imelda C HansonSection of Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Alfred GillioPediatric Blood and Marrow Transplant Program, Hackensack University Medical Center, Hackensack, NJ.
Blachy J Dávila SaldañaDivision of Blood and Marrow Transplantation & Allergy and Immunology, Children's National Medical Center, Washington, DC.
Hermann EibelCentre of Chronic Immunodeficiency, Medical Center, and.
Gregory HopkinsDivision of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.
Jolan E WalterDivision of Pediatric Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA.
Jennifer S WhangboDivision of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.
Donald B KohnMattel Children's Hospital, University of California, Los Angeles, Mattel Children's Hospital, Los Angeles, CA.
Jennifer M PuckDivision of Allergy/Immunology/Blood & Marrow Transplantation, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Morton J CowanDivision of Allergy/Immunology/Blood & Marrow Transplantation, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Linda M GriffithDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Elie HaddadDepartment of Pediatrics, University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada.
Richard J O'ReillyBone Marrow Transplant Program, Memorial Sloan Kettering Cancer Center, New York, NY.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Sung-Yun PaiDivision of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA.ORCID 0000-0002-0158-8147
Boston Children's Hospital · USUniversity of California, San Francisco · USCentre Hospitalier Universitaire Sainte-Justine · CAMemorial Sloan Kettering Cancer Center · USNational Institutes of Health · USUniversity of Southern California · USBaylor College of Medicine · USChildren's National · USDuke Medical Center · USHackensack University Medical Center · USMassachusetts General Hospital · USMattel Children's Hospital · USMedical College of Wisconsin · USPrimary Children's Hospital · USUniversity of Freiburg · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MData Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2MPB vs. BMU01HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2001 to 2010
$63.3MRare Diseases Data Management and Coordinating CenterU01TR001263 · NCATS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2018
$28.1MTraining of Clinical Investigators in Primary Immune DeficienciesU54AI082973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAI, SUNG-YUN · 2009 to 2023
$23.3MData Management and Coordinating Center (DMCC)U54NS064808 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2009 to 2013
$16.5MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MPediatric Blood and Marrow Transplant ConsortiumU01HL069254 · NHLBI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI PULSIPHER, MICHAEL A · 2001 to 2010
$2.0MBlood and Marrow Transplant Clinical Trials NetworkU10HL069254 · NHLBI · UNIVERSITY OF UTAH · PI PULSIPHER, MICHAEL A · 2011 to 2016
$839kPrimary Immune Deficiency Treatment Consortium Annual Scientific MeetingR13AI094943 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2011 to 2025
$239kNCATS NIH HHS U01 TR001263NCI NIH HHS P30 CA008748NCI NIH HHS U24 CA076518NHLBI NIH HHS U01 HL069254NHLBI NIH HHS U01 HL069294NHLBI NIH HHS U10 HL069254NIAID NIH HHS R13 AI094943NIAID NIH HHS U54 AI082973NINDS NIH HHS U54 NS064808
Abstract
Allogeneic hematopoietic stem cell transplant (HSCT) typically results in donor T-cell engraftment and function in patients with severe combined immunodeficiency (SCID), but humoral immunity, particularly when using donors other than matched siblings, is variable. B-cell function after HSCT for SCID depends on the genetic cause, the use of pre-HSCT conditioning, and whether donor B-cell chimerism is achieved. Patients with defects in
Indexed as
AdolescentB-LymphocytesCell DifferentiationChildChild, PreschoolFemaleHematopoietic Stem Cell TransplantationHumansImmunity, HumoralInterleukin-21Interleukin Receptor Common gamma SubunitInterleukinsJanus Kinase 3Lymphocyte ActivationMaleSevere Combined ImmunodeficiencyIL2RG protein, humanInterleukin-21Interleukin Receptor Common gamma SubunitInterleukinsJAK3 protein, humanJanus Kinase 3
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01346150ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.