ArticleApplied and environmental microbiology2018
Effects of Ceftiofur and Chlortetracycline on the Resistomes of Feedlot Cattle.
Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Impact of ceftiofur administration andmSystems · 2026Article
- Early-life development of the microbiome and resistome in antibiotic-naïve dairy calves.Microbiology spectrum · 2026Article
- A comprehensive ruminant microbial catalog (CRMC) reveals convergent selection for key vitamin-synthesizing pathways and genes across ruminants and human.GigaScience · 2026Article
- The fecal resistome of beef cattle from conventional grain-fed and grass-fed systems in the Western United States.BMC microbiology · 2025Article
- Co-Occurrence Patterns of Bacterial Communities and Resistance Genes: A Comprehensive Multi-Pen Fecal Microbiome and Resistome Study in Dairy Farms.Microorganisms · 2025Article
- Quantifying Dissemination of Antibiotic Resistance Genes in Air from a Dairy Farm and Swine Farm.ACS ES&T air · 2025Article
- Landscape of mobile genetic elements and their functional cargo across the gastrointestinal tract microbiomes in ruminants.Microbiome · 2025Article
- Impact of Parenteral Ceftiofur on Developmental Dynamics of Early Life Fecal Microbiota and Antibiotic Resistome in Neonatal Lambs.Antibiotics (Basel, Switzerland) · 2025Article
- Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.Applied and environmental microbiology · 2025Article
- A metagenomic catalogue of the ruminant gut archaeome.Nature communications · 2024Article
- A compendium of ruminant gastrointestinal phage genomes revealed a higher proportion of lytic phages than in any other environments.Microbiome · 2024Article
- Impact of systemic antimicrobial therapy on the faecal microbiome in symptomatic dairy cows.PloS one · 2024Article
- Article
- Long-Term Effects of Single-Dose Cephalosporin or Macrolide Use on the Prevalence of AmpC and Extended-Spectrum β-Lactamase ProducingMicroorganisms · 2022Article
- Resistomes and microbiome of meat trimmings and colon content from culled cows raised in conventional and organic production systems.Animal microbiome · 2022Article
- Evaluating the effects of antimicrobial drug use on the ecology of antimicrobial resistance and microbial community structure in beef feedlot cattle.Frontiers in microbiology · 2022Article
- A review of the resistome within the digestive tract of livestock.Journal of animal science and biotechnology · 2021Review
- Enrofloxacin Alters Fecal Microbiota and Resistome Irrespective of Its Dose in Calves.Microorganisms · 2021Article
- Metagenomic Characterization of the Microbiome and Resistome of Retail Ground Beef Products.Frontiers in microbiology · 2020Article
- Whole genome sequencing and metagenomics for outbreak investigation, source attribution and risk assessment of food-borne microorganisms.EFSA journal. European Food Safety Authority · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
Treatment of food-producing animals with antimicrobial drugs (AMD) is controversial because of concerns regarding promotion of antimicrobial resistance (AMR). To investigate this concern, resistance genes in metagenomic bovine fecal samples during a clinical trial were analyzed to assess the impacts of treatment on beef feedlot cattle resistomes. Four groups of cattle were exposed, using a 2-by-2 factorial design, to different regimens of antimicrobial treatment. Injections of ceftiofur crystalline-free acid (a third-generation cephalosporin) were used to treat all cattle in treatment pens or only a single animal, and either chlortetracycline was included in the feed of all cattle in a pen or the feed was untreated. On days 0 and 26, respectively, pre- and posttrial fecal samples were collected, and resistance genes were characterized using shotgun metagenomics. Treatment with ceftiofur was not associated with changes to β-lactam resistance genes. However, cattle fed chlortetracycline had a significant increase in relative abundance of tetracycline resistance genes. There was also an increase of an AMR class not administered during the study, which is a possible indicator of coselection of resistance genes. Samples analyzed in this study had previously been evaluated by culture characterization (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.