Evidence map›Paper›PMID 29728377›Full record

ArticleApplied and environmental microbiology2018

Mutant Variants of the Substrate-Binding Protein DppA from Escherichia coli Enhance Growth on Nonstandard γ-Glutamyl Amide-Containing Peptides.

Tilmann Kuenzl, Xiaochun Li-Blatter, Puneet Srivastava, Piet Herdewijn, Timothy Sharpe, Sven Panke

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tilmann KuenzlBioprocess Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Xiaochun Li-BlatterBiophysics Facility, Biozentrum, University of Basel, Basel, Switzerland.
Puneet SrivastavaLaboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Piet HerdewijnLaboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Timothy SharpeBiophysics Facility, Biozentrum, University of Basel, Basel, Switzerland.
Sven PankeBioprocess Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland sven.panke@bsse.ethz.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The import of nonnatural molecules is a recurring problem in fundamental and applied aspects of microbiology. The dipeptide permease (Dpp) of

Indexed as

MutationAmidesBacterial ProteinsBiological TransportDipeptidesEscherichia coliEscherichia coli Proteinsgamma-GlutamyltransferaseGlutamic AcidGlutathioneKineticsMembrane Transport ProteinsMetabolic Networks and PathwaysPeptidesPeriplasmic Binding ProteinsSubstrate SpecificityAmidesBacterial ProteinsDipeptidesdppA protein, E coliEscherichia coli Proteinsgamma-GlutamyltransferaseGlutamic AcidGlutathioneMembrane Transport Proteinsoligopeptide permease, BacteriaPeptidesPeriplasmic Binding ProteinsABC transportersadaptive laboratory evolutiondipeptide permeasegamma-glutamyl transferaseisothermal titration calorimetrymembrane transportpeptide transportportage transportsubstrate specificitysynthetic biologyγ-glutamyl transferase

Identifiers

PMID29728377
PMCPMC6007095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.