Trial reportMayo Clinic proceedings2018
Experimental Weight Gain Increases Ambulatory Blood Pressure in Healthy Subjects: Implications of Visceral Fat Accumulation.
Trial report in Mayo Clinic proceedings, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The role of bariatric surgery in hypertension control: a systematic review and meta-analysis with extended benefits on metabolic factors.BMC cardiovascular disorders · 2025Pooled it
- Reduction in Multiple Cardiometabolic Risk Factors With Combined Olanzapine/Samidorphan Compared With Olanzapine: Post Hoc Analyses From a 24-Week Phase 3 Study.Schizophrenia bulletin · 2023Trial
- Mild sleep restriction increases 24-hour ambulatory blood pressure in premenopausal women with no indication of mediation by psychological effects.American heart journal · 2020Trial
- BMI Was Maintained Among Women with Low Incomes in Indiana Who Participated in Food Assistance and/or Federal Nutrition Education Over 1 Year.Current developments in nutrition · 2026Article
- Adherence to Mediterranean Diet and Implications for Cardiovascular Risk Prevention.Nutrients · 2025Observational
- Observational
- Weight gain and higher blood pressure: is it just fat?Journal of hypertension · 2025Article
- Association between cardiometabolic index and hypertension among US adults from NHANES 1999-2020.Scientific reports · 2025Article
- Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes.Cardiovascular diabetology · 2025Article
- Blood pressure is elevated in the absence of resistance artery dysfunction in a mouse model of diet-induced obesity.Frontiers in physiology · 2025Article
- Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure.Current hypertension reports · 2024Review
- Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity.Frontiers in endocrinology · 2023Article
- Cardiovascular Disease Risk Reduction and Body Mass Index.Current hypertension reports · 2022Review
- Effects of Maternal Pre-Pregnancy BMI and Gestational Weight Gain on the Development of Preeclampsia and Its Phenotypes: A Prospective Cohort Study in China.Journal of clinical medicine · 2022Article
- Western diet augments metabolic and arterial dysfunction in a sex-specific manner in outbred, genetically diverse mice.Frontiers in nutrition · 2022Article
- Article
- Overfeeding-induced weight gain elicits decreases in sex hormone-binding globulin in healthy males-Implications for body fat distribution.Physiological reports · 2021Article
- Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Weight gain in Chinese youth during a 4-month COVID-19 lockdown: a retrospective observational study.BMJ open · 2021Observational
- Obstructive Sleep Apnea as a Cardiovascular Risk Factor-Beyond CPAP.The Canadian journal of cardiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine whether experimentally induced weight gain raises ambulatory blood pressure (BP) in healthy subjects and identify any relationship between changes in BP and changes in regional fat distribution. PATIENTS AND
methodsTwenty-six normal weight subjects were randomized to 8 weeks of weight gain through overfeeding (n=16; age, 30.4±6.6 years) or to weight maintenance (controls; n=10; age, 27.1±7.7 years) between July 2004 and August 2010. Measures of body composition via dual energy X-ray absorptiometry and computed tomography, circulating biomarkers, and 24-hour ambulatory BP were obtained at baseline and after the 8-week experimental phase.
resultsOverfeeding resulted in 3.7 kg (95% CI, 2.9-4.5) increase in body weight in weight gainers, with increments in total (46.2 cm
conclusionModest weight gain causes elevation in 24-hour BP in healthy subjects. The association between increased BP and abdominal visceral fat accumulation suggests that visceral deposition of adipose tissue may contribute specifically to the enhanced risk of hypertension associated with weight gain.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.