ArticleParasites & vectors2018
Transplacental transmission of tick-borne Babesia microti in its natural host Peromyscus leucopus.
Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mapping the Global Distribution ofTransboundary and emerging diseases · 2025Pooled it
- Global meta-analysis onPathogens and global health · 2022Pooled it
- Rodent-Borne Parasites and Human Disease: A Growing Public Health Concern.Animals : an open access journal from MDPI · 2025Review
- Small mammals as hosts of vector-borne pathogens in the High Tatra Mountains region in Slovakia, Central Europe.Current research in parasitology & vector-borne diseases · 2025Article
- Tick-Borne Diseases and Pregnancy: A Narrative Review Evaluating Pregnancy Complications Caused by Tick-Borne Diseases.Tropical medicine and infectious disease · 2024Review
- Host-pathogen associations inferred from bloodmeal analyses ofApplied and environmental microbiology · 2024Article
- DoTropical medicine and infectious disease · 2024Article
- Effects of residential acaricide treatments on patterns of pathogen coinfection in blacklegged ticks.Parasitology · 2024Article
- Histopathological Aspects of the Influence ofVeterinary sciences · 2024Article
- Ecological interactions driving population dynamics of two tick-borne pathogens,Proceedings. Biological sciences · 2023Article
- Histopathological Analysis of Selected Organs of Rats with Congenital Babesiosis Caused byVeterinary sciences · 2023Article
- In Silico Survey and Characterization ofPathogens (Basel, Switzerland) · 2021Article
- Ticks, Human Babesiosis and Climate Change.Pathogens (Basel, Switzerland) · 2021Review
- Vertical Transmission: A Vector-Independent Transmission Pathway of Babesia microti in the Natural Reservoir Host Peromyscus leucopus.The Journal of infectious diseases · 2021Article
- Impact of Babesia microti infection on the initiation and course of pregnancy in BALB/c mice.Parasites & vectors · 2021Article
- Congenital Transmission of Apicomplexan Parasites: A Review.Frontiers in microbiology · 2021Review
- Article
- Prevalence, distribution, and diversity of cryptic piroplasm infections in raccoons from selected areas of the United States and Canada.International journal for parasitology. Parasites and wildlife · 2019Article
- Review
- The role of juvenile Dermacentor reticulatus ticks as vectors of microorganisms and the problem of 'meal contamination'.Experimental & applied acarology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundBabesia microti is an emerging tick-borne pathogen and the causative agent of human babesiosis. Mathematical modeling of the reproductive rate of B. microti indicates that it cannot persist in nature by horizontal tick-host transmission alone. We hypothesized that transplacental transmission in the reservoir population contributes to B. microti persistence and emergence in North American rodent populations.
methodsPeromyscus leucopus were collected from Connecticut and Block Island, Rhode Island and analyzed using a highly specific quantitative PCR (qPCR) assay for infection with B. microti.
resultsIn April, 100% (n = 103) of mice were infected with B. microti. Females exhibited significantly higher parasitemia than their offspring (P < 0.0001) and transplacental transmission was observed in 74.2% of embryos (n = 89). Transplacental transmission of B. microti is thus a viable and potentially important infectious pathway in naturally infected rodent species and should be considered in future theoretical and empirical studies.
conclusionsTo our knowledge, this study is the first to report transplacental transmission of B. microti occurring in its natural reservoir host, P. leucopus, in the United States and the only study that provides a quantitative estimate of parasitemia. This vector-independent pathway could contribute to the increased geographic range of B. microti or increase its abundance in endemic areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.