ArticleBMC pregnancy and childbirth2018
Vomiting in pregnancy is associated with a higher risk of low birth weight: a cohort study.
Article in BMC pregnancy and childbirth, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Nausea and Vomiting in Pregnancy: Prevalence, Clinical Characteristics, and Management Findings from a Prospective Italian Multicenter Cohort Study.Life (Basel, Switzerland) · 2026Article
- Adverse Neonatal Outcomes in Pregnant Women with Severe Vomiting: A Meta-Analysis.Iranian journal of public health · 2025Review
- The IRIS clinic: A Protocol for a mixed-methods study evaluating the management of Hyperemesis Gravidarum.Contemporary clinical trials communications · 2024Article
- Re-examining the adaptive function of nausea and vomiting in pregnancy.Evolution, medicine, and public health · 2024Article
- Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study.Archives of gynecology and obstetrics · 2023Article
- Effect of maternal and child factors on stunting: partial least squares structural equation modeling.Clinical and experimental pediatrics · 2022Article
- Article
- Nausea, vomiting and poor appetite during pregnancy and adverse birth outcomes in rural Nepal: an observational cohort study.BMC pregnancy and childbirth · 2020Observational
- Risk Factors of Prolonged Nausea and Vomiting During Pregnancy.Risk management and healthcare policy · 2020Article
- Risk factors for low birth weight in hospitals of North Wello zone, Ethiopia: A case-control study.PloS one · 2019Article
- Combining and Using the Utrecht Method and the Analytic Hierarchy Process to Facilitate Professional and Ethical Deliberation and Decision Making in Complementary and Alternative Medicine: A Case Study among a Panel of Stakeholders.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.Wellcome open research · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
backgroundLow birth weight has important short- and long-term health implications. Previously it has been shown that pregnancies affected by hyperemesis gravidarum in the mother are at higher risk of having low birth weight offspring. In this study we tested whether such risks are also evident with less severe nausea and vomiting in pregnancy.
methodsOne thousand two hundred thirty-eight women in the prospective Cambridge Baby Growth Study filled in pregnancy questionnaires which included questions relating to adverse effects of pregnancy and drugs taken during that time. Ordinal logistic regression models, adjusted for parity, ethnicity, marital and smoking status were used to relate the risk of giving birth to low birth weight (< 2.5 kg) babies to nausea and/or vomiting in pregnancy that were not treated with anti-emetics and did not report suffering from hyperemesis gravidarum.
resultsOnly three women in the cohort reported having had hyperemesis gravidarum although a further 17 women reported taking anti-emetics during pregnancy. Of those 1218 women who did not take anti-emetics 286 (23.5%) did not experience nausea or vomiting, 467 (38.3%) experienced nausea but not vomiting and 465 experienced vomiting (38.2%). Vomiting during pregnancy was associated with higher risk of having a low birth weight baby (odds ratio 3.5 (1.2, 10.8), p = 0.03). The risk associated with vomiting was found in the first (p = 0.01) and second (p = 0.01) trimesters but not the third (p = 1.0). The higher risk was not evident in those women who only experienced nausea (odds ratio 1.0 (0.3, 4.0), p = 1.0).
conclusionsVomiting in early pregnancy, even when not perceived to be sufficiently severe to merit treatment, is associated with a higher risk of delivering a low birth weight baby. Early pregnancy vomiting might therefore be usable as a marker of higher risk of low birth weight in pregnancy. This may be of benefit in situations where routine ultrasound is not available to distinguish prematurity from fetal growth restriction, so low birth weight is used as an alternative.
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