Evidence map›Paper›PMID 29727701›Full record

ArticleNeurotoxicology and teratology

Prenatal exposure to tobacco and cannabis: Effects on autonomic and emotion regulation.

Rina D Eiden, Pamela Schuetze, Shannon Shisler, Marilyn A Huestis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Prenatal substance exposure and early childhood adversity: implications for child autonomic functioning at early school-age.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
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  13. Prenatal Substance Exposure.Annual review of developmental psychology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Rina D EidenUniversity at Buffalo, State University of New York. Electronic address: eiden@ria.buffalo.edu.
Pamela SchuetzeState University of New York at Buffalo State, United States.
Shannon ShislerUniversity at Buffalo, State University of New York.
Marilyn A HuestisInstitute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, United States.
University at Buffalo, State University of New York · USBuffalo State University · USThomas Jefferson University · US

Funding

Prenatal & ETS Exposure: Effects on Child RegulationR01DA019632 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EIDEN, RINA D · 2006 to 2016
$5.8M
NIDA NIH HHS R01 DA019632
6 · The paper itself

Abstract

Tobacco and cannabis are often used together in pregnancy and both have effects on children's regulatory system. Yet, little is known about the impact of co-use on the development of emotion regulation at the developmentally salient age of 2 years. One pathway linking co-exposure to tobacco and cannabis to toddler regulation may be via poor autonomic regulation in infancy. In addition, substance using mothers may be more dysregulated themselves, which may have direct effects on toddler regulation, but may also affect parenting, particularly maternal sensitivity during mother-child interactions. Thus, a second pathway linking exposure to toddler regulation may be via maternal dysregulation and low maternal sensitivity. We examined a conceptual model linking prenatal exposure to toddler regulation via these two pathways in a prospective sample (N = 247) of mother-child dyads recruited in the first trimester of pregnancy. Results indicated significant effects of co-exposure on poor autonomic regulation in infancy, which in turn predicted poor toddler emotion regulation. Mothers who used both tobacco and cannabis displayed lower sensitivity during play interactions with their infants. Maternal sensitivity was modestly stable from infant to toddler period and was predictive of higher toddler emotion regulation. Continued postnatal exposure to tobacco was also a significant, unique predictor of lower toddler emotion regulation. Results highlight the importance of examining co-exposure effects and suggest that this common pattern of use may be associated with higher infant/toddler risks.

Indexed as

AdolescentAdultAutonomic Nervous SystemCannabisCase-Control StudiesChild, PreschoolDrug InteractionsEmotionsFemaleHumansMaleModels, PsychologicalMother-Child RelationsPregnancyPrenatal Exposure Delayed EffectsProspective StudiesAutonomic regulationCannabisEmotion regulationMaternal sensitivityPrenatal adversityTobacco

Identifiers

PMID29727701
PMCPMC6161361
OpenAlexW2799597772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.