ArticleCell stem cell2018
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.
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Article in Cell stem cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers, 1 of them a synthesis that pooled it.
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264citing papers in PubMed, 1 pooled it
19.1field-weighted citation impact, top 1% of its field
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Who cites it
264 citing papers in PubMed, 1 synthesis or guideline pooled it, 401 citations in OpenAlex.
- Effect of Calorie Restriction and Intermittent Fasting Regimens on Brain-Derived Neurotrophic Factor Levels and Cognitive Function in Humans: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Trial
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- CPT1A-mediated IDO1 succinylation shapes EGFRvIII-driven resistance to tumor electric field therapy in glioblastoma.Nature communications · 2026Article
- Westernized diet related arachidonic acid metabolism expands DNA error-prone growth factor-dependent colonic quiescent stem cells in adolescent mice.Cell death & disease · 2026Article
- Intestinal epithelial memory: from inflammatory imprinting to metabolite-shaped immune tolerance.Barrier immunity · 2026Article
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
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- TNFR1 signaling connects inflammation to impaired fatty acid oxidation to drive intestinal stem cell aging.Nature aging · 2026Article
- Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging.Science advances · 2026Article
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- Modified Shen Ling Bai Zhu San Combined with Its Essential Oil Regulates Growth Performance, Lipid Metabolism and Intestinal Health in Silky Fowls.Animals : an open access journal from MDPI · 2026Article
- Intermittent fasting alters the antigen-specific CD5+ B-1 cell natural antibody repertoire in male and female mice.ImmunoHorizons · 2026Article
- An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.Nature immunology · 2026Article
- Interplay of the ENS and Microbiota With Murine Gut Epithelium-Derived Organoids in Aging.Aging cell · 2026Article
- Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming.Nature communications · 2026Article
- Time-restricted feeding improves functional capacity of adipose-derived stem cells with activation of OSK-associated transcriptional programs.npj aging · 2026Article
204 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 10 institutions in 5 countries.
Maria M MihaylovaWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Chia-Wei ChengThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Amanda Q CaoWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Surya TripathiThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA.
Miyeko D ManaThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Khristian E Bauer-RoweThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Monther Abu-RemailehWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Laura ClavainWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Aysegul ErdemirThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Faculty of Arts & Sciences, Department of Molecular Biology and Genetics, Yildiz Technical University, 34210 Istanbul, Turkey.
Caroline A LewisWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Elizaveta FreinkmanWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Audrey S DickeyDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
Albert R La SpadaDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
Yanmei HuangWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
George W BellWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Vikram DeshpandeDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Peter CarmelietLaboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, 3000 Leuven, Belgium.
Pekka KatajistoInstitute of Biotechnology, HiLIFE, University of Helsinki, P.O. Box 56, Helsinki, Finland; Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Stockholm, Sweden.
David M SabatiniWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: sabatini@wi.mit.edu.
Ömer H YilmazThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: ohyilmaz@mit.edu.
Whitehead Institute for Biomedical Research · USBroad Institute · USKoch Institute for Integrative Cancer Research At MITDuke University · USHarvard University · USHoward Hughes Medical Institute · USMassachusetts General Hospital · USUniversity of Helsinki · FIVIB-KU Leuven Center for Cancer Biology · BEYıldız Technical University · TR
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3MRegulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MUnderstanding and Improving Platinum Anticancer DrugsR01CA034992 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 1985 to 2018
$6.8MProject 2U54CA224068 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CORCORAN, RYAN BRUCE, FLAHERTY, KEITH T · 2017 to 2021
$6.3MThe PPAR-delta pathway in neural function and Huntington's disease neuropathologyR01NS065874 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LA SPADA, ALBERT R · 2010 to 2020
$4.0MMolecular genetic regulation of autophagy in health and neurodegenerative diseaseR01AG033082 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LA SPADA, ALBERT R · 2009 to 2019
$4.0MDietary control of stem cells in physiology and cancerR01CA211184 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2017 to 2021
$2.0MUnderstanding the Mechanisms of Age-Dependent Decline of Intestinal Stem Cell FunctionR00AG054760 · NIA · OHIO STATE UNIVERSITY · PI MIHAYLOVA, MARIA M. · 2018 to 2020
$747kRegulation of the Intestinal Stem Cell Niche in AgingR00AG045144 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2014 to 2016
$740kUnderstanding the Mechanisms of Age-Dependent Decline of Intestinal Stem Cell FunctionK99AG054760 · NIA · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI MIHAYLOVA, MARIA M. · 2017 to 2018
$224kHoward Hughes Medical InstituteNCI NIH HHS R01 CA034992NCI NIH HHS R01 CA103866NCI NIH HHS R01 CA211184NCI NIH HHS U54 CA224068NIA NIH HHS K99 AG054760NIA NIH HHS R00 AG045144NIA NIH HHS R00 AG054760NIA NIH HHS R01 AG033082NIDDK NIH HHS P30 DK043351NINDS NIH HHS R01 NS065874
Abstract
Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting. Acute genetic disruption of Cpt1a, the rate-limiting enzyme in FAO, abrogates ISC-enhancing effects of fasting, but long-term Cpt1a deletion decreases ISC numbers and function, implicating a role for FAO in ISC maintenance. These findings highlight a role for FAO in mediating pro-regenerative effects of fasting in intestinal biology, and they may represent a viable strategy for enhancing intestinal regeneration.
Indexed as
AgingHomeostasisAnimalsCells, CulturedFastingFatty AcidsIntestinesMiceMice, Inbred StrainsOxidation-ReductionStem CellsFatty Acidsagingfastingfatty acid oxidationintestinal stem cellsintestinemetabolismmitochondrial metabolismstem cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.