ArticleMolecular cell2018
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.
Open access · bronzeAbstract read
In one paragraph
Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- In Vitro Anti-Breast Cancer Effects ofInternational journal of molecular sciences · 2026Article
- PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling.Translational stroke research · 2026Article
- Pip5k1α defines a mandible-specific phosphoinositide signaling axis in mice.Science China. Life sciences · 2026Article
- Article
- A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks.The Journal of biological chemistry · 2026Article
- Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B.Acta crystallographica. Section D, Structural biology · 2026Article
- Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Orthosteric-allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer.Journal of advanced research · 2026Article
- Noncanonical PI(4,5)PScience advances · 2026Article
- Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026Review
- Matrix stiffness induces CaExperimental hematology & oncology · 2026Article
- PARP inhibitors accumulate B7-H3 on fibroblasts via blocking autophagic flux to potentiate immune evasion in ovarian cancer.Oncoimmunology · 2025Article
- Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease.Clinical science (London, England : 1979) · 2025Review
- Application of chemical similarity and bioisosteres to find allosteric inhibitors of type 2 lipid kinase γ.Scientific reports · 2025Article
- PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer.Cell reports · 2025Article
- PI5P4K inhibitors: promising opportunities and challenges.The FEBS journal · 2025Review
- PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.Nature communications · 2025Article
- Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity.Aging and disease · 2025Review
- Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities.Nature reviews. Cancer · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 9 institutions in 4 countries.
Mark R LundquistMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Marcus D GoncalvesMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Ryan M LoughranSanford Burnham Prebys Medical Discovery Institute, Cancer Metabolism and Signaling Networks Program, La Jolla, CA 92037, USA.
Elite PossikGoodman Cancer Research Center, McGill University, Montréal, Québec, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3G 1Y6, Canada.
Tarika VijayaraghavanGoodman Cancer Research Center, McGill University, Montréal, Québec, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3G 1Y6, Canada.
Annan YangDivision of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Chantal PauliMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY 10065, USA.
Archna RaviSanford Burnham Prebys Medical Discovery Institute, Cancer Metabolism and Signaling Networks Program, La Jolla, CA 92037, USA.
Akanksha VermaMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA.
Zhiwei YangMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Jared L JohnsonMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Jenny C Y WongMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Yilun MaMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Katie Seo-Kyoung HwangMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
David WeinkoveSchool of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK.
Nullin DivechaThe Inositide Laboratory, Centre for Biological Sciences, Southampton University, Southampton, SO17 1BJ, UK.
John M AsaraDepartment of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Olivier ElementoMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA.
Mark A RubinMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY 10065, USA.
Alec C KimmelmanPerlmutter Cancer Center, Department of Radiation Oncology, NYU Medical School, New York, NY 10016, USA.
Arnim PauseGoodman Cancer Research Center, McGill University, Montréal, Québec, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3G 1Y6, Canada.
Lewis C CantleyMeyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: lcantley@med.cornell.edu.
Brooke M EmerlingSanford Burnham Prebys Medical Discovery Institute, Cancer Metabolism and Signaling Networks Program, La Jolla, CA 92037, USA. Electronic address: bemerling@sbpdiscovery.org.
Cornell University · USMcGill University · CASanford Burnham Prebys Medical Discovery Institute · USNewYork–Presbyterian Hospital · USBeth Israel Deaconess Medical Center · USDana-Farber Cancer Institute · USDurham University · GBNYU Langone Health · USUniversity of Southampton · GB
Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2MThe RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7MRole of Phosphoinositides and Protein Kinases in the control of Cancer MetabolismR35CA197588 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEWIS C. CANTLEY · 2016 to 2026
$10.2MProject 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI FISCHBACH, CLAUDIA · 2016 to 2020
$10.2MThe Role of PI3K in Growth RegulationR01GM041890 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CANTLEY, LEWIS C. · 1990 to 2016
$4.1MNetwork organization of the human autophagy systemR01GM095567 · NIGMS · HARVARD MEDICAL SCHOOL · PI HARPER, JEFFREY W, KIMMELMAN, ALEC · 2011 to 2018
$3.0MInvestigating the Role of Autophagy in Pancreatic Cancer Radiation ResistanceR01CA157490 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIMMELMAN, ALEC · 2011 to 2018
$2.5MInvestigating a Novel Glutamine Metabolism Pathway in Pancreatic CancerR01CA188048 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIMMELMAN, ALEC · 2015 to 2018
$1.5MNCI NIH HHS P01 CA117969NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA157490NCI NIH HHS R01 CA188048NCI NIH HHS R35 CA197588NCI NIH HHS U54 CA210184NIGMS NIH HHS R01 GM041890NIGMS NIH HHS R01 GM095567
Abstract
While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P
Indexed as
AnimalsAutophagosomesAutophagyCaenorhabditis elegansCell LineFastingFibroblastsHEK293 CellsHumansLipid MetabolismLiverMicePhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Signal Transduction1-phosphatidylinositol-4-phosphate 5-kinasephosphatidylinositol 4-phosphatephosphatidylinositol 5-phosphatePhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)autophagylipid kinaselysosomemetabolismmTORC1phospholipidPI5P4KTFEB
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.