ArticlePLoS computational biology2018
Differential polarization of cortical pyramidal neuron dendrites through weak extracellular fields.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review.Neuropsychology review · 2024Pooled it
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- Multi-scale model of neural entrainment by transcranial alternating current stimulation in realistic cortical anatomy.Journal of computational neuroscience · 2025Article
- Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem.PLoS computational biology · 2025Article
- Effects of transcranial alternating current stimulation on Spike train correlation in two-compartment model neurons.Biological cybernetics · 2025Article
- Transcranial electrical stimulation (TES) in human motor Optimization: Mechanisms, safety, and emerging applications.Biochemistry and biophysics reports · 2025Review
- Morphological variability may limit single-cell specificity to electric field stimulation.Frontiers in synaptic neuroscience · 2025Article
- Article
- Frequency-domain analysis of membrane polarization in two-compartment model neurons with weak alternating electric fields.Cognitive neurodynamics · 2024Article
- Cell class-specific electric field entrainment of neural activity.bioRxiv : the preprint server for biology · 2024Article
- Less might be more: 1 mA but not 1.5 mA of tDCS improves tactile orientation discrimination.IBRO neuroscience reports · 2023Article
- Intensity- and frequency-specific effects of transcranial alternating current stimulation are explained by network dynamics.bioRxiv : the preprint server for biology · 2023Article
- Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation.Trends in cognitive sciences · 2023Review
- Neurophysiological mechanisms of transcranial alternating current stimulation.Frontiers in neuroscience · 2023Review
- Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform.Nature communications · 2021Article
- Dose-dependent effects of transcranial alternating current stimulation on spike timing in awake nonhuman primates.Science advances · 2020Article
- Biophysically grounded mean-field models of neural populations under electrical stimulation.PLoS computational biology · 2020Article
- Astroglial Isopotentiality and Calcium-Associated Biomagnetic Field Effects on Cortical Neuronal Coupling.Cells · 2020Review
- Age-Dependent Effect of Transcranial Alternating Current Stimulation on Motor Skill Consolidation.Frontiers in aging neuroscience · 2020Article
- Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes.Journal of neuroengineering and rehabilitation · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rise of transcranial current stimulation (tCS) techniques have sparked an increasing interest in the effects of weak extracellular electric fields on neural activity. These fields modulate ongoing neural activity through polarization of the neuronal membrane. While the somatic polarization has been investigated experimentally, the frequency-dependent polarization of the dendritic trees in the presence of alternating (AC) fields has received little attention yet. Using a biophysically detailed model with experimentally constrained active conductances, we analyze the subthreshold response of cortical pyramidal cells to weak AC fields, as induced during tCS. We observe a strong frequency resonance around 10-20 Hz in the apical dendrites sensitivity to polarize in response to electric fields but not in the basal dendrites nor the soma. To disentangle the relative roles of the cell morphology and active and passive membrane properties in this resonance, we perform a thorough analysis using simplified models, e.g. a passive pyramidal neuron model, simple passive cables and reconstructed cell model with simplified ion channels. We attribute the origin of the resonance in the apical dendrites to (i) a locally increased sensitivity due to the morphology and to (ii) the high density of h-type channels. Our systematic study provides an improved understanding of the subthreshold response of cortical cells to weak electric fields and, importantly, allows for an improved design of tCS stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.