ArticlePLoS biology2018
Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 41 citations in OpenAlex.
- Stochastic theory for pattern formation and front propagation in transitional pipe turbulence.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Solution landscape of reaction-diffusion systems reveals a nonlinear mechanism and spatial robustness of pattern formation.Fundamental research · 2026Article
- Co-option of an ancestral peptidase controls developmental patterning in multicellular cyanobacteria.iScience · 2026Article
- Spatio-temporal coherence of circadian clocks and temporal control of differentiation inmSystems · 2024Article
- PatU3 plays a central role in coordinating cell division and differentiation in pattern formation of filamentous cyanobacterium Nostoc sp. PCC 7120.Science China. Life sciences · 2023Article
- Stochastic Turing patterns of trichomes inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Terminal heterocyst differentiation in the Anabaena patA mutant as a result of post-transcriptional modifications and molecular leakage.PLoS computational biology · 2022Article
- Ecological drivers of division of labour in Streptomyces.Current opinion in microbiology · 2022Review
- Mathematical models of nitrogen-fixing cell patterns in filamentous cyanobacteria.Frontiers in cell and developmental biology · 2022Review
- Turing pattern design principles and their robustness.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Review
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- HetL, HetR and PatS form a reaction-diffusion system to control pattern formation in the cyanobacteriumeLife · 2020Article
- Expression from DIF1-motif promoters of hetR and patS is dependent on HetZ and modulated by PatU3 during heterocyst differentiation.PloS one · 2020Article
- Noise⁻Seeded Developmental Pattern Formation in Filamentous Cyanobacteria.Life (Basel, Switzerland) · 2018Review
- Stochastic Turing patterns in a synthetic bacterial population.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under nitrogen deprivation, the one-dimensional cyanobacterial organism Anabaena sp. PCC 7120 develops patterns of single, nitrogen-fixing cells separated by nearly regular intervals of photosynthetic vegetative cells. We study a minimal, stochastic model of developmental patterns in Anabaena that includes a nondiffusing activator, two diffusing inhibitor morphogens, demographic fluctuations in the number of morphogen molecules, and filament growth. By tracking developing filaments, we provide experimental evidence for different spatiotemporal roles of the two inhibitors during pattern maintenance and for small molecular copy numbers, justifying a stochastic approach. In the deterministic limit, the model yields Turing patterns within a region of parameter space that shrinks markedly as the inhibitor diffusivities become equal. Transient, noise-driven, stochastic Turing patterns are produced outside this region, which can then be fixed by downstream genetic commitment pathways, dramatically enhancing the robustness of pattern formation, also in the biologically relevant situation in which the inhibitors' diffusivities may be comparable.
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