Evidence map›Paper›PMID 29727371›Full record

ArticleCritical care medicine2018

Mortality Measures to Profile Hospital Performance for Patients With Septic Shock.

Allan J Walkey, Meng-Shiou Shieh, Vincent X Liu, Peter K Lindenauer

Abstract read
In one paragraph

Article in Critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Intravenous to Oral Antibiotic Switch Therapy Among Patients Hospitalized With Community-Acquired Pneumonia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Allan J WalkeyDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, Center for Implementation and Improvement Sciences, Boston University School of Medicine, Boston, MA.
Meng-Shiou ShiehInstitute for Healthcare Delivery and Population Science and Department of Medicine, University of Massachusetts Medical School - Baystate, Springfield, MA.
Vincent X LiuKaiser Permanente Division of Research, Oakland, CA.
Peter K LindenauerInstitute for Healthcare Delivery and Population Science and Department of Medicine, University of Massachusetts Medical School - Baystate, Springfield, MA.

Funding

Automated detection and prediction of atrial fibrillation during sepsisR01HL136660 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALKEY, ALLAN J. · 2017 to 2020
$2.2M
Data-driven Precision medicine in sepsisK23GM112018 · NIGMS · KAISER FOUNDATION RESEARCH INSTITUTE · PI LIU, VINCENT · 2014 to 2017
$768k
Atrial Fibrillation in Sepsis: Patient Outcomes and Provider Practice PatternsK01HL116768 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALKEY, ALLAN J. · 2013 to 2017
$742k
Research and Mentoring in Comparative Effectiveness and Implementation ScienceK24HL132008 · NHLBI · BAYSTATE MEDICAL CENTER, INC. · PI LINDENAUER, PETER KYLE · 2016 to 2020
$574k
NHLBI NIH HHS K01 HL116768NHLBI NIH HHS K24 HL132008NHLBI NIH HHS R01 HL136660NIGMS NIH HHS K23 GM112018
6 · The paper itself

Abstract

objectivesSepsis care is becoming a more common target for hospital performance measurement, but few studies have evaluated the acceptability of sepsis or septic shock mortality as a potential performance measure. In the absence of a gold standard to identify septic shock in claims data, we assessed agreement and stability of hospital mortality performance under different case definitions.

designRetrospective cohort study.

settingU.S. acute care hospitals. PATIENTS: Hospitalized with septic shock at admission, identified by either implicit diagnosis criteria (charges for antibiotics, cultures, and vasopressors) or by explicit International Classification of Diseases, 9th revision, codes.

interventionsNone. MEASUREMENTS AND MAIN

resultsWe used hierarchical logistic regression models to determine hospital risk-standardized mortality rates and hospital performance outliers. We assessed agreement in hospital mortality rankings when septic shock cases were identified by either explicit International Classification of Diseases, 9th revision, codes or implicit diagnosis criteria. Kappa statistics and intraclass correlation coefficients were used to assess agreement in hospital risk-standardized mortality and hospital outlier status, respectively. Fifty-six thousand six-hundred seventy-three patients in 308 hospitals fulfilled at least one case definition for septic shock, whereas 19,136 (33.8%) met both the explicit International Classification of Diseases, 9th revision, and implicit septic shock definition. Hospitals varied widely in risk-standardized septic shock mortality (interquartile range of implicit diagnosis mortality: 25.4-33.5%; International Classification of Diseases, 9th revision, diagnosis: 30.2-38.0%). The median absolute difference in hospital ranking between septic shock cohorts defined by International Classification of Diseases, 9th revision, versus implicit criteria was 37 places (interquartile range, 16-70), with an intraclass correlation coefficient of 0.72, p value of less than 0.001; agreement between case definitions for identification of outlier hospitals was moderate (kappa, 0.44 [95% CI, 0.30-0.58]).

conclusionsRisk-standardized septic shock mortality rates varied considerably between hospitals, suggesting that septic shock is an important performance target. However, efforts to profile hospital performance were sensitive to septic shock case definitions, suggesting that septic shock mortality is not currently ready for widespread use as a hospital quality measure.

Indexed as

AgedAged, 80 and overAnti-Bacterial AgentsBenchmarkingCritical IllnessFemaleHospital MortalityHumansLogistic ModelsMaleMiddle AgedQuality Indicators, Health CareRetrospective StudiesRisk AssessmentSepsisShock, SepticAnti-Bacterial AgentsVasoconstrictor Agents

Identifiers

PMID29727371
PMCPMC6045435

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.