Evidence map›Paper›PMID 29727175›Full record

ArticleJournal of the American Chemical Society2018

Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR.

Alberto Ceccon, Thomas Schmidt, Vitali Tugarinov, Samuel A Kotler, Charles D Schwieters, G Marius Clore

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  12. Review
  13. NMR illuminates intrinsic disorder.Current opinion in structural biology · 2021
    Review
  14. Review
  15. Review
  16. Amino acid homorepeats in proteins.Nature reviews. Chemistry · 2020
    Review
  17. Article
  18. Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Article
  20. Exosomes as Actively Targeted Nanocarriers for Cancer Therapy.International journal of nanomedicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alberto CecconLaboratory of Chemical Physics , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , Maryland 20892-520 , United States.
Thomas SchmidtLaboratory of Chemical Physics , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , Maryland 20892-520 , United States.
Vitali TugarinovLaboratory of Chemical Physics , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , Maryland 20892-520 , United States.
Samuel A KotlerLaboratory of Chemical Physics , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , Maryland 20892-520 , United States.
Charles D SchwietersImaging Sciences Laboratory , Center for Information Technology, National Institutes of Health , Bethesda , Maryland 20892-5624 , United States.
G Marius CloreLaboratory of Chemical Physics , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , Maryland 20892-520 , United States.ORCID 0000-0003-3809-1027
National Institutes of Health · US

Funding

Structure and Dynamics Of Macromolecules In Solution By NMRZIADK029023 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CLORE, GIDEON · 2009 to 2025
$41.5M
Biomedical ImagingZIACT000090 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI TRUS, BENES L · 2009 to 2018
$7.8M
NMR STUDIES OF THREE-DIMENSIONAL STRUCTURE OF MACROMOLECULES IN SOLUTIONZ01DK029023 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CLORE, G. MARIUS · 1988 to 2008
$949k
Misfolding and aggregation of polyglutamine sequences in neurodegenerative diseasesFI2GM117609 · NIGMS · U.S. NATIONAL INST DIABETES/DIGST/KIDNEY · PI KOTLER, SAMUEL A · 2016 to 2016
–
Intramural NIH HHS Z01 DK029023NIGMS NIH HHS FI2 GM117609
6 · The paper itself

Abstract

Lipid-based micellar nanoparticles promote aggregation of huntingtin exon-1 peptides. Here we characterize the interaction of two such peptides, htt

Indexed as

MicellesElectron Spin Resonance SpectroscopyHumansHuntingtin ProteinLipidsModels, MolecularNanoparticlesNuclear Magnetic Resonance, BiomolecularPeptidesProtein AggregatesProtein Conformation, alpha-HelicalProtein DomainsProtein MultimerizationHTT protein, humanHuntingtin ProteinLipidsMicellesPeptidespolyglutamineProtein Aggregates

Identifiers

PMID29727175
PMCPMC6034506
OpenAlexW2800788078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.