Evidence map›Paper›PMID 29725990›Full record

ArticleMolecular diagnosis & therapy2018

Gene Expression Analysis of Immunomagnetically Enriched Circulating Tumor Cell Fraction in Castration-Resistant Prostate Cancer.

Markéta Škereňová, Veronika Mikulová, Otakar Čapoun, David Švec, Katarína Kološtová, Viktor Soukup, Hana Honová, Tomáš Hanuš, Tomáš Zima

Abstract read
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In one paragraph

Article in Molecular diagnosis & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Markéta ŠkereňováInstitute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 12808, Prague, Czech Republic. jancikova.market@gmail.com.ORCID 0000-0002-7165-4410
Veronika MikulováInstitute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 12808, Prague, Czech Republic.ORCID 0000-0002-9962-5312
Otakar ČapounDepartment of Urology, General University Hospital and First Faculty of Medicine, Charles University in Prague, Ke Karlovu 6, 12808, Prague, Czech Republic.ORCID 0000-0002-2332-3174
David ŠvecLaboratory of Gene Expression, Institute of Biotechnology CAS, Průmyslová 595, 252 50, Vestec, Czech Republic.
Katarína KološtováInstitute of Laboratory Diagnostics, Third Faculty of Medicine, Charles University in Prague, Šrobárova 1150/50, 100 34, Prague, Czech Republic.
Viktor SoukupDepartment of Urology, General University Hospital and First Faculty of Medicine, Charles University in Prague, Ke Karlovu 6, 12808, Prague, Czech Republic.ORCID 0000-0001-5313-9629
Hana HonováDepartment of Oncology, General University Hospital in Prague and First Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 12808, Prague, Czech Republic.
Tomáš HanušDepartment of Urology, General University Hospital and First Faculty of Medicine, Charles University in Prague, Ke Karlovu 6, 12808, Prague, Czech Republic.
Tomáš ZimaInstitute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 12808, Prague, Czech Republic.ORCID 0000-0001-8518-6972
Charles University · CZCzech Academy of Sciences, Institute of Biotechnology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMolecular characterization of tumors could be a key to therapeutic decision-making with regards to targeted therapies in castration-resistant prostate cancer (CRPC). A convenient solution may be non-invasive liquid biopsy testing of circulating tumor cells (CTCs). For this reason, CTC-enriched samples obtained by immunomagnetic separation (AdnaTest PATIENTS AND

methodsCTC-enriched samples from 41 CRPC patients previously determined to be CTC positive using the AdnaTest

resultsThe AdnaTest

conclusionDetection of AR expression by AdnaTest

Indexed as

Biomarkers, TumorGene Expression ProfilingAgedAged, 80 and overFollow-Up StudiesGenetic TestingHigh-Throughput Screening AssaysHumansImmunomagnetic SeparationMaleMiddle AgedNeoplastic Cells, CirculatingProstatic Neoplasms, Castration-ResistantReal-Time Polymerase Chain ReactionTranscriptomeBiomarkers, Tumor

Identifiers

PMID29725990
OpenAlexW2800108237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.