Evidence map›Paper›PMID 29725907›Full record

SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018

Genetic Factors Associated with Postoperative Nausea and Vomiting: a Systematic Review.

Pedro López-Morales, Diego Flores-Funes, Elena González Sánchez-Migallón, Ramón José Lirón-Ruiz, José Luis Aguayo-Albasini

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Pharmacogenetic and clinical predictors of ondansetron failure in a diverse pediatric oncology population.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pedro López-MoralesFaculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, University of Murcia, Murcia, Spain.
Diego Flores-FunesFaculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, University of Murcia, Murcia, Spain. diego.ff90@gmail.com.ORCID 0000-0001-5644-3706
Elena González Sánchez-MigallónFaculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, University of Murcia, Murcia, Spain.
Ramón José Lirón-RuizFaculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, University of Murcia, Murcia, Spain.
José Luis Aguayo-AlbasiniFaculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, University of Murcia, Murcia, Spain.
Hospital General Universitario Morales Meseguer · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn previous studies, there seems to be a relationship between different genetic polymorphisms and postoperative nausea and vomiting (PONV). We perform a systematic review of the current literature about the relationship between genetic polymorphisms and the presence of PONV.

methodsTwo bibliographic searches were carried out in three databases (PubMed, Web of Science, and Scopus) of studies, preferably prospective, about PONV following abdominal surgery. It was completed with a backward citation searching. A total of 73 articles were found of which 6 were selected after their critical lecture using CASPe network criteria. Relative frequency and relative risk were taken in each study according to the polymorphism.

resultsStudies about 5-HT3B gene receptor polymorphisms, ABCB1 transporter, and dopamine D2 receptor showed a significant association with the presence of PONV (p = 0.02, 0.01, and 0.034 respectively). In relation to cytochrome P-450 2D6 (CYP2D6) polymorphisms, two of the three analysed articles showed a significant association with postoperative vomiting (p = 0.007).

conclusionGenetic polymorphisms could play an important role in PONV. The AAG deletion in both alleles of the 5-HT3B receptor gene, the Taq IA polymorphism of the dopamine D2 receptor, and the presence of three or more functional alleles of CYP2D6 seem to be related with a higher incidence of PONV, especially in the first 24 h after surgery. The 2677TT and 3435TT genotypes of the ABCB1 transporter could reduce the PONV due to their association with a greater effectiveness of ondansetron. However, new quality studies are needed to consider this relationship.

Indexed as

ATP Binding Cassette Transporter, Subfamily BCytochrome P-450 CYP2D6HumansPolymorphism, GeneticPostoperative Nausea and VomitingReceptors, Dopamine D2Receptors, Serotonin, 5-HT3ABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BCytochrome P-450 CYP2D6DRD2 protein, humanReceptors, Dopamine D2Receptors, Serotonin, 5-HT3Genetic polymorphismOndansetronPostoperative nausea and vomitingRisk factorUltrarapid metaboliser

Identifiers

PMID29725907
OpenAlexW2801822089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.