Evidence map›Paper›PMID 29725850›Full record

ArticleClinical oral investigations2019

The association with xerostomia from sialadenitis and the jaw osteonecrosis in head and neck cancer population: a nationwide cohort study.

Yi-Fang Huang, Chih-Hsin Muo, Chun-Hao Tsai, Shih-Ping Liu, Chung-Ta Chang

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Tumor subsites and risk of osteoradionecrosis of the jaw in patients with oral cavity cancer: a national-based cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Yi-Fang HuangDepartment of General Dentistry, Chang Gung Memorial Hospital, Linkou, 33305, Taiwan.
Chih-Hsin MuoManagement Office for Health Data, China Medical University Hospital, Taichung, 40402, Taiwan.
Chun-Hao TsaiDepartment of Orthopedics, China Medical University Hospital, Taichung, 40402, Taiwan.
Shih-Ping LiuGraduate Institute of Basic Medical Science, China Medical University, No. 91, Hsueh-Shih Road, Taichung City, 40402, Taiwan. spliu@mail.cmuh.org.tw.
Chung-Ta ChangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan. chungta2001@gmail.com.ORCID http://orcid.org/0000-0002-9211-1407
China Medical University · TWAsia University · TWChang Gung Memorial Hospital · TWFar Eastern Memorial Hospital · TW

Funding

Academia Sinica BM10501010037Chang Gung Memorial Hospital, Linkou CMRPG3C1791Chang Gung Memorial Hospital, Linkou CMRPG3E1341Far Eastern Memorial Hospital FEMH-2016-C-036Ministry of Health and Welfare MOHW105-TDU-B-212-133019National Research Program for Biopharmaceuticals MOST 104-2325-B-039-005
6 · The paper itself

Abstract

objectivesDetermine the association between sialadenitis and osteonecrosis of the jaw (ONJ) in head and neck cancer (HNC) patients with varying severity of sialadenitis, treatment modalities, and cancer locations. MATERIALS AND

methodsA total of 40,168 HNC patients, including 1907 ONJ subjects and 7559 matched comparisons, were enrolled from a Longitudinal Health Insurance Database for Catastrophic Illness Patients of Taiwan between 2000 and 2006. The association with sialadenitis and ONJ was estimated by logic regression and presented as the odds ratio (OR) and 95% confidence intervals (CIs).

resultsThe occurrence of sialadenitis increased the risk of ONJ by 2.55-fold in HNC patients (95% CI = 2.20-2.95). The ONJ incidence was proportion to sialadenitis severity (OR = 2.53 to 4.43). Irradiated HNC patients had a higher tendency to develop jaw necrosis (osteoradionecrosis, ORN) (OR = 5.05, 95% CI = 4.39-5.80). When combined with irradiation exposure, sialadenitis significantly induced the occurrence of ORN (OR = 8.94, 95% CI = 7.40-10.8), especially in oral cancer patients (OR = 15.9 95% CI = 12.5-20.3). The risk of ONJ increased with radiotherapy dosage and duration, except for nasopharyngeal cancer (NPC) patients.

conclusionsThere was a close association between sialadenitis and ONJ in the HNC population. The severity of sialadenitis was positive correlated to ONJ risk. Radiotherapy combined with sialadenitis significantly raised ORN incidence in HNC patients except for NPC patients. CLINICAL RELEVANCE: HNC patients complained that xerostomia from sialadenitis might increase the risk to develop ONJ, especially among those who received radiotherapy.

Indexed as

AgedBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsCase-Control StudiesDiphosphonatesFemaleHead and Neck NeoplasmsHumansIncidenceLongitudinal StudiesMaleMiddle AgedOsteoradionecrosisRadiotherapy DosageRisk FactorsSialadenitisBone Density Conservation AgentsDiphosphonatesHead and neck cancerOsteonecrosis of the jawOsteoradionecrosisPopulation-basedRadiotherapySialadenitis

Identifiers

PMID29725850
OpenAlexW2802713983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.