SynthesisJournal of neurology2018
Motor neuron disease of paraneoplastic origin: a rare but treatable condition.
Synthesis in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bibrachial amyotrophy as a rare manifestation of intraspinal fluid collection: a case report and systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Facial onset sensory and motor neuronopathy (FOSMN syndrome): Cases series and systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Paraneoplastic Brachial Amyotrophic Diplegia and Encephalitis With Ma2-IgG During Immune Checkpoint Inhibitor Use for Mesothelioma: A Case Report.JTO clinical and research reports · 2026Article
- Alternative diagnoses of suspected paraneoplastic neurological syndromes: a population-based study.Journal of neurology · 2026Article
- Motor neuron disease can present as a paraneoplastic neurologic syndrome with various phenotypes.Brain communications · 2026Article
- Paraneoplastic Brachial Amyotrophic Diplegia With Favorable Outcome and Anti-Ank3 Antibodies: A Case Report.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Neuroaxonal Degeneration as a Converging Mechanism in Motor Neuron Diseases (MNDs): Molecular Insights into RNA Dysregulation and Emerging Therapeutic Targets.International journal of molecular sciences · 2025Review
- Upper motor neuron-predominant motor neuron disease: a novel immunotherapy-responsive association of GAD65 autoimmunity.Journal of neurology · 2025Article
- Anti-Hu associated paraneoplastic upper and lower motor neuropathy triggered by atezolizumab.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Clinical and serological insights into paraneoplastic brachial amyotrophic diplegia.Journal of neurology · 2024Article
- Case report: Paraneoplastic lower motor neuronopathy associated with a malignant liver tumor.Frontiers in neurology · 2024Article
- Iranian clinical practice guideline for amyotrophic lateral sclerosis.Frontiers in neurology · 2023Review
- Paraneoplastic Amyotrophic Lateral Sclerosis: Case Series and Literature Review.Brain sciences · 2022Article
- Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis.Acta neuropathologica · 2021Article
- Molecular Pathology of ALS: What We Currently Know and What Important Information Is Still Missing.Diagnostics (Basel, Switzerland) · 2021Review
- Granzyme B in peripheral blood mononuclear cells as a measure of cell-mediated immune response in paraneoplastic neurological syndromes and malignancy.Cancer immunology, immunotherapy : CII · 2021Article
- Paraneoplastic Myeloneuropathies: Clinical, Oncologic, and Serologic Accompaniments.Neurology · 2021Observational
- Immunophenotypical characterization of paraneoplastic neurological syndrome patients: a multicentric study.Journal of biosciences · 2021Article
- Paraneoplastic Neurological Syndromes: Study of Prevalence in a Province of the Lombardy Region, Italy.Journal of clinical medicine · 2020Article
- Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark.Clinical epidemiology · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paraneoplastic motor neuron disorders (MND) are rare conditions; their exact clinical and electrophysiological phenotype have not been exhaustively described yet. The purpose of this study is to depict the main characteristics of paraneoplastic MND to highlight the features that may allow its diagnosis. Based on the description of eight original cases, and on the revision of 21 patients identified from a systematic review of the literature, the main features of paraneoplastic MND can be summarized as follows: (1) subacute; (2) lower motor neuron syndrome, associated or not with upper motor neuron involvement; (3) predominant asymmetric upper limb involvement; (4) presence of other non-motor neurological manifestations, including sensory neuronopathy; (5) signs of inflammation in the cerebrospinal fluid (CSF); (6) neurological improvement or stabilization after immunotherapy and tumor treatment. The diagnosis of paraneoplastic MND may be difficult because of its rarity, the absence of pathognomonic clinical features, and the frequent absence of prior tumor history. However, it is of capital importance to correctly identify patients with paraneoplastic MND, as this represents a potentially treatable condition. In the presence of subacute lower motor neuron impairment, especially when atypical clinical features for degenerative MND or other non-motor neurological manifestations are present, we recommend testing for onconeural antibodies. In the case, the search for onconeural antibodies is negative, but it exists a strong clinical suspicion for a paraneoplastic etiology; CSF analysis and total-body 18FDG-PET/CT imaging should be performed to circumstantiate diagnosis.
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