Evidence map›Paper›PMID 29725804›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

Validation of the EPIPHANY index for predicting risk of serious complications in cancer patients with incidental pulmonary embolism.

Shin Ahn, Tim Cooksley, Srinivas Banala, Luke Buffardi, Terry W Rice

Abstract readObservational StudyValidation Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Emerging challenges in the evaluation of fever in cancer patients at risk of febrile neutropenia in the era of COVID-19: a MASCC position paper.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Guideline
  2. Article
  3. Risk stratification for clinical severity of pulmonary embolism in patients with cancer: a narrative review and MASCC clinical guidance for daily care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Review
  4. Review
  5. Review
  6. Outpatient management of incidental pulmonary embolism in cancer patient.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Shin AhnDepartment of Emergency Medicine, Cancer Emergency Room, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Tim CooksleyDepartment of Acute and Critical Care, The Christie, Manchester, UK.
Srinivas BanalaDepartment of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA.
Luke BuffardiMorehouse School of Medicine, Atlanta, GA, USA.
Terry W RiceDepartment of Emergency Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. TWRice@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USBaylor College of Medicine · USMorehouse School of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe EPIPHANY index was developed to classify cancer associated pulmonary embolism (PE) into different risk categories using decision tree modeling. In this study, we tried to externally validate this index in a distinct group of patients solely composed of incidental PE (IPE).

methodsA retrospective study of patients diagnosed with IPE in two Emergency Departments in the USA and South Korea from 2013 to 2014 was performed. The primary outcome was the occurrence of a serious medical complication within 15 days of presentation to ED. Thirty-day complication was the secondary outcome. Cumulative hazard curves for each prognostic category were drawn to show the change in hazards over time.

resultsA total of 258 patients with IPE were included (193 from MD Anderson Cancer Center and 65 from Asan Medical Center). Serious complication within 15 days occurred in 23 (8.9%) patients. The risk of overall 15-day and 30-day serious complications increased with each category (low, intermediate, and high risk: 3.4, 8.9, and 23.8%, P = 0.033; 6.9, 9.5, and 33.3%, P = 0.011). Cumulative hazard curves for each prognostic category were drawn and the survival functions factored by prognostic categories were significantly different over 15 days (P = 0.015) and 30 days (P = 0.001).

conclusionsOur study suggests the EPIPHANY index could be a useful adjunct tool in risk stratification of cancer patients with IPE.

Indexed as

Decision Support TechniquesSeverity of Illness IndexAdultAgedDecision TreesFemaleHumansMaleMiddle AgedNeoplasmsPrognosisPulmonary EmbolismRepublic of KoreaRetrospective StudiesRisk AssessmentRisk FactorsCancerComplicationIncidental pulmonary embolismOncologic emergenciesVenous thromboembolism

Identifiers

PMID29725804
OpenAlexW2801805780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.