ArticleHeart and vessels2018
Mean platelet volume is associated with serum 25-hydroxyvitamin D concentrations in patients with stable coronary artery disease.
Article in Heart and vessels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Comparative Study on the Effect of Vitamin D Deficiency on Platelet Indices in COVID-19 and Hepatitis C Patients; an Observational Comparative Study.Health science reports · 2026Article
- Association between 25(OH)D levels and clinical outcomes in patients infected with SARS-CoV-2: a cross-sectional study.Scientific reports · 2025Article
- The effect of vitamin D deficiency on platelet parameters in patients with COVID-19.Frontiers in cellular and infection microbiology · 2024Article
- Vitamin D in atherosclerosis and cardiovascular events.European heart journal · 2023Review
- Review
- Mechanisms Suggesting a Relationship between Vitamin D and Erectile Dysfunction: An Overview.Biomolecules · 2023Review
- 25-Hydroxy Vitamin D Level and Its Correlation with Mean Platelet Volume in Preeclampsia.Iranian journal of public health · 2022Article
- The Association between Vitamin D Levels and Thrombus Burden in Patients with ST-Elevation Myocardial Infarction.The journal of Tehran Heart Center · 2022Article
- Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity.Journal of clinical medicine · 2022Article
- The Association of 25-Hydroxy Vitamin D level with Mean Platelet Volume in Patients with Acute Coronary Syndrome.Cardiovascular & hematological disorders drug targets · 2022Article
- Discordance between Body-Mass Index and Body Adiposity Index in the Classification of Weight Status of Elderly Patients with Stable Coronary Artery Disease.Journal of clinical medicine · 2021Article
- A Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review.Journal of inflammation research · 2021Review
- Association between Multiplate-measured aspirin resistance and vitamin D deficiency in stable coronary artery disease.Archives of medical sciences. Atherosclerotic diseases · 2021Article
- Serum Gamma Glutamyltransferase Is Associated with 25-Hydroxyvitamin D Status in Elderly Patients with Stable Coronary Artery Disease.International journal of environmental research and public health · 2020Article
- Hydroxyvitamin D Serum Levels are Negatively Associated with Platelet Number in a Cohort of Subjects Affected by Overweight and Obesity.Nutrients · 2020Article
- Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis.Biomolecules · 2019Review
- Vitamin D deficiency and atrial fibrillation: A cross sectional single center study.ARYA atherosclerosisArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is little published data on the association of platelet function and 25(OH)D concentration. We investigated the associations between mean platelet volume (MPV) and 25(OH)D concentration in patients with stable coronary artery disease. Study population was divided into three groups: group 1-25(OH)D < 10 ng/mL (N = 22), group 2-25(OH)D 10-20 ng/mL (N = 42), and group 3-25(OH)D > 20 ng/mL (N = 14). Study groups shared similar demographics. MPV values were the highest in group 1, moderate in group 2, and the lowest in group 3 (11.1 vs 10.4 vs 9.8 fL P < 0.001). There was a negative correlation between MPV and 25(OH)D (R = - 0.38, P = 0.001). ROC analysis demonstrated a moderate predictive value (AUC 0.70) in identifying the discrimination thresholds of MPV (> 10.5 fL) for vitamin D deficiency and a weak predictive value (AUC 0.65) in identifying the discrimination thresholds of 25(OH)D concentration (≤ 15.5 ng/mL) for the presence of large platelets (MPV over the upper limit of normal). In conclusion, even though the effect of vitamin D on platelet size and function is probably multifactorial, our study provides further evidence linking vitamin D to thrombosis and hemostasis. Platelets are another potential element through which vitamin D deficiency could exert adverse cardiovascular outcomes.
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