Evidence map›Paper›PMID 29725647›Full record

ArticleKidney international reports2018

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin-Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H-Related Protein-5 (FHR5) Deposition.

Nicholas R Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J Lomax-Browne, Annette G Hansen, Michelle Willicombe, Charles D Pusey, H Terence Cook, Steffen Thiel, Matthew C Pickering

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 95 citations in OpenAlex.

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  15. Complement System Inhibitors in Nephrology: An Update-Narrative Review.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Nicholas R Medjeral-ThomasCentre for Complement and Inflammation Research, Imperial College London, London, UK.
Anne TroldborgDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Nicholas ConstantinouCentre for Complement and Inflammation Research, Imperial College London, London, UK.
Hannah J Lomax-BrowneCentre for Complement and Inflammation Research, Imperial College London, London, UK.
Annette G HansenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Michelle WillicombeRenal and Transplant Centre, Imperial College Healthcare NHS Trust, London, UK.
Charles D PuseyRenal and Vascular Inflammation Section, Imperial College London, London, UK.
H Terence CookCentre for Complement and Inflammation Research, Imperial College London, London, UK.
Steffen ThielDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Matthew C PickeringCentre for Complement and Inflammation Research, Imperial College London, London, UK.
Centre for Inflammation Research · GBImperial College London · GBAarhus University · DKAarhus University Hospital · DKImperial College Healthcare NHS Trust · GB

Funding

Medical Research Council MR/K01353X/1Wellcome Trust
6 · The paper itself

Abstract

introductionIgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal injury.

methodsTo elucidate the contribution of the lectin pathway to IgAN, we measured the 11 plasma lectin pathway components in a well-characterized cohort of patients with IgAN.

resultsM-ficolin, L-ficolin, mannan-binding lectin (MBL)-associated serine protease (MASP)-1 and MBL-associated protein (MAp) 19 were increased, whereas plasma MASP-3 levels were decreased in patients with IgAN compared with healthy controls. Progressive disease was associated with low plasma MASP-3 levels and increased glomerular staining for C3b/iC3b/C3c, C3d, C4d, C5b-9, and factor H-related protein 5 (FHR5). Glomerular FHR5 deposition positively correlated with glomerular C3b/iC3b/C3c, C3d, and C5b-9 deposition, but not with glomerular C4d. These observations, together with the finding that glomerular factor H (fH) deposition was reduced in progressive disease, are consistent with a role for fH deregulation by FHR5 in renal injury in IgAN.

conclusionOur data indicate that circulating MASP-3 levels could be used as a biomarker of disease severity in IgAN and that glomerular staining for FHR5 could both indicate alternative complement pathway activation and be a tissue marker of disease severity.

Indexed as

complementIgA nephropathylectinMBL

Identifiers

PMID29725647
PMCPMC5932138
OpenAlexW2768469552

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.