ArticleKidney international reports2018
Proton Pump Inhibitor Usage and the Risk of Mortality in Hemodialysis Patients.
Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association between proton pump inhibitor use and the risk of mortality in patients with kidney disease: a systematic review and meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- Proton pump inhibitors associated with an increased risk of mortality in elderly: a systematic review and meta-analysis.European journal of clinical pharmacology · 2024Pooled it
- Ten tips for the first hemodialysis sessions.Clinical kidney journal · 2026Review
- Bone health, renal outcomes, and iron deficiency anaemia in proton pump inhibitor versus histamine-2 receptor antagonist users: a retrospective cohort study based on TriNetX global collaborative network data.BMJ open gastroenterology · 2025Article
- Use of Proton Pump Inhibitors Is Not Associated with Post-Dialysis Fatigue and Time of Recovery after Dialysis in Patients on Maintenance Hemodialysis.Journal of clinical medicine · 2024Article
- Effects of Proton Pump Inhibitors on Patient Survival in Patients Undergoing Maintenance Hemodialysis.Journal of clinical medicine · 2023Article
- A Retrospective Analysis of Risk Factors for Mortality during Hemodialysis at a General Hospital That Treats Comprehensive Diseases.Internal medicine (Tokyo, Japan) · 2023Article
- Development and Validation of a Predictive Risk Algorithm for Bleeding in Individuals on Long-term Hemodialysis: An International Prospective Cohort Study (BLEED-HD).Canadian journal of kidney health and disease · 2023Article
- Proton pump inhibitor usage is associated with higher all-cause mortality and CV events in peritoneal dialysis patients.Renal failure · 2022Article
- The Impact of Occupational Noise on Hypertension Risk: A Case-Control Study in Automobile Factory Personnel.Frontiers in cardiovascular medicine · 2022Article
- Prognostic impact of polypharmacy by drug essentiality in patients on hemodialysis.Scientific reports · 2021Article
- Use of proton pump inhibitors in dialysis patients: a double-edged sword?Journal of nephrology · 2021Review
- Anti-Acid Drug Treatment Induces Changes in the Gut Microbiome Composition of Hemodialysis Patients.Microorganisms · 2021Article
- Trabecular bone score may indicate chronic kidney disease-mineral and bone disorder (CKD-MBD) phenotypes in hemodialysis patients: a prospective observational study.BMC nephrology · 2020Observational
- The association between use of proton-pump inhibitors and excess mortality after kidney transplantation: A cohort study.PLoS medicine · 2020Observational
- Review
- The Authors Reply.Kidney international reports · 2019Article
- Increased Proton Pump Inhibitors-Induced Mortality Risk in Hemodialysis Patients.Kidney international reports · 2019Article
- Proton pump inhibitors and 180-day mortality in the elderly afterGut pathogens · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLong-term inappropriate proton pump inhibitors use (PPIs) is a matter of concern because of the risks associated with their long-term use in older patients with chronic conditions. The risk of PPI treatment in hemodialysis patients remains unexplored.
methodsWe assessed the relationship between the use of PPIs and the risk of death in hemodialysis patients throughout a retrospective multicenter propensity score-matched study. Information about demographic, hemodialysis treatment, laboratory data, and concomitant medication was obtained from the EuCliD database (Fresenius Medical Care). We studied 1776 hemodialysis patients on PPI therapy compared to 466 patients not receiving PPIs. The resulting population comprising 2 groups of 410 matched patients was studied.
resultsPPI use was associated with hypomagnesemia (Mg <1.8 mg/dl (0.75 mmol/l); odds ratio [OR] = 2.70, 95% confidence interval [CI] = 1.38-5.27,
conclusionThe study data suggest that the PPI treatment should be regularly monitored and prescribed only when indicated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.