Evidence map›Paper›PMID 29725636›Full record

ArticleKidney international reports2018

Treatment of Hyperkalemia With a Low-Dose Insulin Protocol Is Effective and Results in Reduced Hypoglycemia.

Bairbre A McNicholas, Mai H Pham, Katrina Carli, Chang Huei Chen, Nancy Colobong-Smith, Arthur Eric Anderson, Hien Pham

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06036823 (5 Versus 10 Units of Insulin in Hyperkalemia Management), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06036823 phase4completednot on this mapstarted 2023, after this paper: background citation

5 Versus 10 Units of Insulin in Hyperkalemia Management: Multi-center, Prospective, Double-blind, Non-inferiority, Randomized Control Trial.

TypeinterventionalSponsorOman Medical Speciality BoardRan2023 to 2025Enrolled384ConditionsHyperkalemia, Potassium Imbalance, Electrolyte Imbalance, Electrolyte DisturbanceArmsInsulin regular, Dextrose 50, salbutamol
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Emergency department referral and short-term death after outpatient hyperkalemia: a population-based study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Hyperkalemia in Diabetes Mellitus Setting.Diseases (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Article
  13. Insulin stimulation reduces aortic wave reflection in adults with metabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  14. Acute hyperkalemia in the emergency department: a summary from a Kidney Disease: Improving Global Outcomes conference.European journal of emergency medicine : official journal of the European Society for Emergency Medicine · 2020
    Review
  15. Article
  16. Acute Management of Hyperkalemia.Current heart failure reports · 2019
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Bairbre A McNicholasDivision of Nephrology, University of Washington, Seattle, Washington, USA.
Mai H PhamDivision of Nephrology, University of Washington, Seattle, Washington, USA.
Katrina CarliDivision of Nephrology, University of Washington, Seattle, Washington, USA.
Chang Huei ChenDivision of Nephrology, University of Washington, Seattle, Washington, USA.
Nancy Colobong-SmithDivision of Nephrology, University of Washington, Seattle, Washington, USA.
Arthur Eric AndersonDivision of Nephrology, University of Washington, Seattle, Washington, USA.
Hien PhamDivision of Nephrology, University of Washington, Seattle, Washington, USA.
University of Washington · USSaolta University Health Care Group · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionComplications associated with insulin treatment for hyperkalemia are serious and common. We hypothesize that, in chronic kidney disease (CKD) and end-stage renal disease (ESRD), giving 5 units instead of 10 units of i.v. regular insulin may reduce the risk of causing hypoglycemia when treating hyperkalemia.

methodsA retrospective quality improvement study on hyperkalemia management (K

resultsTreatments ordered using a protocol for hyperkalemia increased following the educational intervention (58 of 78 patients [74%] vs. 62 of 99 patients [62%]), and the number of CKD/ESRD patients prescribed 5 units of insulin as per protocol increased (30 of 32 patients [93%] vs. 32 of 43 [75%],

conclusionEducation on the use of a protocol for hyperkalemia resulted in a reduction in the number of patients with severe hypoglycemia associated with insulin treatment.

Indexed as

adverse eventscomputerized physician order entryend-stage renal diseasehyperkalemiahypoglycemia

Identifiers

PMID29725636
PMCPMC5932119
OpenAlexW2765960660

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.