Evidence map›Paper›PMID 29725554›Full record

ArticleFatigue : biomedicine, health & behavior2017

Distinct Evening Fatigue Profiles in Oncology Outpatients Receiving Chemotherapy.

Fay Wright, Bruce A Cooper, Yvette P Conley, Marilyn J Hammer, Lee-May Chen, Steven M Paul, Jon D Levine, Christine Miaskowski, Kord M Kober

Abstract read
In one paragraph

Article in Fatigue : biomedicine, health & behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Joint nausea and fatigue profiles during chemotherapy identify patients with a higher symptom burden.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  8. Prediction of morning fatigue severity in outpatients receiving chemotherapy: less may still be more.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  11. Subgroups of patients undergoing chemotherapy with distinct cognitive fatigue and evening physical fatigue profiles.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  12. Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  14. Higher levels of stress and different coping strategies are associated with greater morning and evening fatigue severity in oncology patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Fay WrightSchool of Nursing, Yale University, New Haven, CT.
Bruce A CooperSchool of Nursing, University of California, San Francisco, CA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA.
Marilyn J HammerMount Sinai Medical Center, New York, NY.
Lee-May ChenSchool of Medicine, University of California, San Francisco, CA.
Steven M PaulSchool of Nursing, University of California, San Francisco, CA.
Jon D LevineSchool of Medicine, University of California, San Francisco, CA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, CA.
Kord M KoberSchool of Nursing, University of California, San Francisco, CA.
University of California, San Francisco · USMount Sinai Medical Center · USUniversity of Pittsburgh · USYale University · US

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
Research Training: Self and Family ManagementT32NR008346 · NINR · YALE UNIVERSITY · PI GREY, MARGARET · 2003 to 2018
$4.7M
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
NCI NIH HHS K05 CA168960NCI NIH HHS R01 CA134900NINR NIH HHS T32 NR008346
6 · The paper itself

Abstract

backgroundFatigue is the most common and debilitating symptom experienced by oncology patients during chemotherapy (CTX). Fatigue severity demonstrates a large amount of inter-individual and diurnal variability. PURPOSE: Study purposes were to evaluate for subgroups of patients with distinct evening fatigue profiles and evaluate how these subgroups differed on demographic, clinical, and symptom characteristics.

methodsOutpatients with breast, gastrointestinal, gynecological, or lung cancer (n=1332) completed questionnaires six times over two cycles of CTX. Lee Fatigue Scale (LFS) evaluated evening fatigue severity. Latent profile analysis was used to identify distinct evening fatigue profiles.

resultsFour distinct evening fatigue classes (i.e., Low (14.0%), Moderate (17.2%), High (36.0%), Very High (32.8%)) were identified. Compared to the Low class, patients in the Very High evening fatigue class were: younger, female, had childcare responsibilities, had more years of education, had a lower functional status, had a higher comorbidity burden, and were diagnosed with breast cancer. Patients in the Very High class reported higher levels of depressive symptoms, sleep disturbance, and evening fatigue at enrollment.

conclusionsFindings provide new insights into modifiable risk factors for higher levels of evening fatigue. Clinicians can use this information to identify higher risk patients and plan appropriate interventions.

Indexed as

chemotherapydiurnal variationsevening fatiguelatent class analysissymptom profiles

Identifiers

PMID29725554
PMCPMC5926814
OpenAlexW2614902300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.