Evidence map›Paper›PMID 29725490›Full record

ArticleStatistical analysis and data mining2018

Whole-Volume Clustering of Time Series Data from Zebrafish Brain Calcium Images via Mixture Modeling.

Hien D Nguyen, Jeremy F P Ullmann, Geoffrey J McLachlan, Venkatakaushik Voleti, Wenze Li, Elizabeth M C Hillman, David C Reutens, Andrew L Janke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Statistical analysis and data mining, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 17 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Hien D NguyenDepartment of Mathematics and Statistics, La Trobe University, Bundoora, Melbourne, Australia 3086.
Jeremy F P UllmannDepartment of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, USA 02115.
Geoffrey J McLachlanSchool of Mathematics and Physics, The University of Queensland, St. Lucia, Brisbane, Australia 4075.
Venkatakaushik VoletiLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Columbia University, New York, New York 10027, USA.
Wenze LiLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Columbia University, New York, New York 10027, USA.
Elizabeth M C HillmanLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Columbia University, New York, New York 10027, USA.
David C ReutensCentre for Advanced Imaging, The University of Queensland, St. Lucia, Brisbane, Australia 4075.
Andrew L JankeCentre for Advanced Imaging, The University of Queensland, St. Lucia, Brisbane, Australia 4075.
Optica · USThe University of Queensland · AUBoston Children's Hospital · USLa Trobe University · AU

Funding

SCAPE microscopy for high-speed 3D imaging of cellular function in behaving animals: Continued innovation, optimization, and disseminationUF1NS108213 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HILLMAN, ELIZABETH M. C. · 2018 to 2018
$3.5M
SCAPE microscopy for high-speed in-vivo volumetric microscopy in behaving organismsU01NS094296 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HILLMAN, ELIZABETH M. C. · 2015 to 2017
$2.0M
NINDS NIH HHS U01 NS094296NINDS NIH HHS UF1 NS108213
6 · The paper itself

Abstract

Calcium is a ubiquitous messenger in neural signaling events. An increasing number of techniques are enabling visualization of neurological activity in animal models via luminescent proteins that bind to calcium ions. These techniques generate large volumes of spatially correlated time series. A model-based functional data analysis methodology via Gaussian mixtures is suggested for the clustering of data from such visualizations is proposed. The methodology is theoretically justified and a computationally efficient approach to estimation is suggested. An example analysis of a zebrafish imaging experiment is presented.

Indexed as

Calcium imagingMixture modelTime series dataZebrafish

Identifiers

PMID29725490
PMCPMC5927610
OpenAlexW2735333363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.