ArticleOncology letters2018
A nomogram for predicting survival in patients with breast cancer brain metastasis.
Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Development and validation of prognostic nomograms for patients with metastatic prostate cancer.International urology and nephrology · 2019Trial
- Individualized prediction of survival after brain metastasis development in patients with breast cancer.Journal of neuro-oncology · 2026Article
- Survival outcomes among patients with breast cancer and leptomeningeal disease.Scientific reports · 2025Article
- Stroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer.Radiology case reports · 2025Article
- Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies.Biomedicines · 2025Review
- Review
- Article
- Association between age and the presence and mortality of breast cancer synchronous brain metastases in the United States: A neglected SEER analysis.Frontiers in public health · 2022Article
- Association between red blood cell distribution width and mortality in patients with metastatic brain tumors: A retrospective single-center cohort study.Frontiers in oncology · 2022Article
- Advances in the management of breast cancer brain metastases.Neuro-oncology advances · 2021Review
- Assessment of Karnofsky (KPS) and WHO (WHO-PS) performance scores in brain tumour patients: the role of clinician bias.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Surgery for primary tumor benefits survival for breast cancer patients with bone metastases: a large cohort retrospective study.BMC cancer · 2021Article
- Article
- Type and timing of systemic therapy use predict overall survival for patients with brain metastases treated with radiation therapy.Journal of neuro-oncology · 2021Article
- NCCBM, a Nomogram Prognostic Model in Breast Cancer Patients With Brain Metastasis.Frontiers in oncology · 2021Article
- A nomogram for determining the disease-specific survival in invasive lobular carcinoma of the breast: A population study.Medicine · 2020Article
- Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function.The Journal of experimental medicine · 2020Article
- Clinical outcome of patients with brain metastases from breast cancer - A population based study over 21 years.Breast (Edinburgh, Scotland) · 2020Article
- microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy.Molecular cancer · 2020Review
- Breast Cancer Brain Metastasis: The Potential Role of MRI Beyond Current Clinical Applications.Cancer management and research · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain metastasis (BM) is common in patients with breast cancer. Predicting patient survival is critical for the clinical management of breast cancer brain metastasis (BCBM). The present study was designed to develop and evaluate a prognostic model for patients with newly diagnosed BCBM. Based on the clinical data of patients with BCBM treated in the Affiliated Hospital of Academy of Military Medical Sciences (Beijing, China) between 2002 and 2014, a nomogram was developed to predict survival using proportional hazards regression analysis. The model was validated internally by bootstrapping, and the concordance index (c-index) was calculated. A calibration curve and c-index were used to evaluate discriminatory and predictive ability, in order to compare the nomogram with widely used models, including recursive partitioning analysis (RPA), graded prognostic assessment (GPA) and breast-graded prognostic assessment (Breast-GPA). A total of 411 patients with BCBM were included in the development of this predictive model. The median overall survival time was 14.1 months. Statistically significant predictors for patient survival included biological subtype, Karnofsky performance score, leptomeningeal metastasis, extracranial metastasis, the number of brain metastases and disease-free survival. A nomogram for predicting 1- and 2-year overall survival rates was constructed, which exhibited good accuracy in predicting overall survival with a concordance index of 0.735. This model outperformed RPA, GPA and Breast-GPA, based on the comparisons of the c-indexes. The nomogram constructed based on a multiple factor analysis was able to more accurately predict the individual survival probability of patients with BCBM, compared with existing models.
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