Evidence map›Paper›PMID 29725404›Full record

ArticleOncology letters2018

Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway.

Yulan Zhen, Qiaomei Wu, Yiqian Ding, Wei Zhang, Yuansheng Zhai, Xiaoxiong Lin, Yunxia Weng, Ruixian Guo, Ying Zhang, Jianqiang Feng and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The potential role of hydrogen sulfide-autophagy axis in diseases.Journal of physiology and biochemistry · 2025
    Review
  5. Sulfide regulation and catabolism in health and disease.Signal transduction and targeted therapy · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Microbiota of the gastrointestinal tract: Friend or foe?World journal of gastroenterology · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Hydrogen Sulfide Biology and Its Role in Cancer.Molecules (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Review
  18. Role of hydrogen sulfide donors in cancer development and progression.International journal of biological sciences · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Yulan ZhenDepartment of Oncology, The Third People's Hospital of Dongguan Dongguan City, Guangdong 523326, P.R. China.
Qiaomei WuDepartment of Anesthesiology, Oral Subsidiary Sun Yat-Sen University Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510700, P.R. China.
Yiqian DingGrade 2013, Medical Imaging, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510000, P.R. China.
Wei ZhangDepartment of Cardiovasology and Cardiac Care Unit, Huangpu Division of The First Affiliated Hospital, Guangzhou, Guangdong 510080, P.R. China.
Yuansheng ZhaiDepartment of Cardiovasology and Cardiac Care Unit, Huangpu Division of The First Affiliated Hospital, Guangzhou, Guangdong 510080, P.R. China.
Xiaoxiong LinDepartment of Cardiovasology and Cardiac Care Unit, Huangpu Division of The First Affiliated Hospital, Guangzhou, Guangdong 510080, P.R. China.
Yunxia WengDepartment of Cardiovasology and Cardiac Care Unit, Huangpu Division of The First Affiliated Hospital, Guangzhou, Guangdong 510080, P.R. China.
Ruixian GuoDepartment of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510700, P.R. China.
Ying ZhangDepartment of Oncology, Affiliated Hospital, Guangdong Medical College, Zhanjiang, Guangdong 524001, P.R. China.
Jianqiang FengDepartment of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510700, P.R. China.
Yiyan LeiDepartment of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China.
Jingfu ChenDepartment of Cardiovascular Medicine and Dongguan Cardiovascular Institute, The Third People's Hospital of Dongguan City, Dongguan, Guangdong 523326, P.R. China.
First Affiliated Hospital of Guangdong Pharmaceutical University · CNSun Yat-sen University · CNDongguan People’s Hospital · CNGuangdong Medical College · CNSouthern Medical University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of hydrogen sulfide (H

Indexed as

COX-2growthhydrogen sulfidePLC/PRF/5 cellsSTAT3

Identifiers

PMID29725404
PMCPMC5920354
OpenAlexW2790650687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.