Evidence map›Paper›PMID 29725359›Full record

ReviewExperimental and therapeutic medicine2018

Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke.

Yingchen Li, Qilai Cheng, Guoheng Hu, Tianhao Deng, Qimei Wang, Jianda Zhou, Xinping Su

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pleiotropic Effects of Exosomes as a Therapy for Stroke Recovery.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yingchen LiPost-doctoral Research Station of Clinical Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
Qilai ChengCollege of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
Guoheng HuDepartment of Neurology, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410007, P.R. China.
Tianhao DengDepartment of Oncology, The Affiliated Hospital of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, P.R. China.
Qimei WangDepartment of Oncology, The Affiliated Hospital of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, P.R. China.
Jianda ZhouDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
Xinping SuDepartment of Osteology, The Affiliated Hospital of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, P.R. China.
Hunan Academy of Traditional Chinese Medicine · CNCentral South University · CNFirst Affiliated Hospital of Hunan University of Traditional Chinese Medicine · CNGannan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A stroke is a focal cerebral insult that frequently causes severe neurological deficit and mortality. Recent studies have demonstrated that multipotent mesenchymal stromal cells (MSCs) hold great promise for neurovascular remodeling and neurological function recovery following a stroke. Rather than a direct replacement of parenchymal brain cells, the therapeutic mechanism of MSCs is suggested to be the secretion of soluble factors. Specifically, emerging data described MSCs as being able to release extracellular vesicles (EVs), which contain a variety of cargo including proteins, lipids, DNA and various RNA species. The released EVs can target neurocytes and vascular cells and modify the cell's functions by delivering the cargo, which are considered to mediate the neural restoration effects of MSCs. Therefore, EVs may be developed as a novel cell-free therapy for neurological disorders. In the present review, the current advances regarding the components, functions and therapeutic potential of EVs are summarized and the use of MSC-derived EVs as a promising approach in the treatment of stroke are highlighted.

Indexed as

exosomesextracellular vesiclesmesenchymal stromal cellsmicrovesiclesstroke

Identifiers

PMID29725359
PMCPMC5920496
OpenAlexW2791700379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.