ArticleFrontiers in plant science2018
Massive Loss of DNA Methylation in Nitrogen-, but Not in Phosphorus-Deficient
Article in Frontiers in plant science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Epigenetic regulation of mycorrhizal symbioses: from plastic responses to transgenerational legacies.The New phytologist · 2026Review
- Epigenetic modifications regulate peg elongation and underground fruiting in peanut in response to environmental cues.The plant genome · 2026Review
- Effects of Different Salinity Conditions on Regulation ofInternational journal of molecular sciences · 2025Article
- Epigenome analysis of an algae-infecting giant virus reveals a unique methylation motif catalogue.PloS one · 2025Article
- Stimulatory effects of smoke solution and biogas digestate slurry application on photosynthesis, growth, and methylation profiling ofPlant signaling & behavior · 2024Article
- Almond Grafting for Plum Pox Virus Resistance Triggers Significant Transcriptomic and Epigenetic Shifts in Peaches.International journal of molecular sciences · 2024Article
- Genome variation and LTR-RT analyses of an ancient peach landrace reveal mechanism of blood-flesh fruit color formation and fruit maturity date advancement.Horticulture research · 2024Article
- Article
- Understanding the evolution of miRNA biogenesis machinery in plants with special focus on rice.Functional & integrative genomics · 2023Article
- Physiological, Biochemical, and Epigenetic Reaction of Maize (International journal of molecular sciences · 2023Article
- Moderate DNA methylation changes associated with nitrogen remobilization and leaf senescence in Arabidopsis.Journal of experimental botany · 2022Article
- Article
- Herbicide stress-induced DNA methylation changes in two Zea mays inbred lines differing in Roundup® resistance.Journal of applied genetics · 2021Article
- Organ-specific expression and epigenetic traits of genes encoding digestive enzymes in the lance-leaf sundew (Drosera adelae).Journal of experimental botany · 2021Article
- Whole-Genome DNA Methylation Analysis in Hydrogen Peroxide Overproducing Transgenic Tobacco Resistant to Biotic and Abiotic Stresses.Plants (Basel, Switzerland) · 2021Article
- Genome-Wide Differential DNA Methylation and miRNA Expression Profiling Reveals Epigenetic Regulatory Mechanisms Underlying Nitrogen-Limitation-Triggered Adaptation and Use Efficiency Enhancement in Allotetraploid Rapeseed.International journal of molecular sciences · 2020Article
- Chromatin regulation in plant hormone and plant stress responses.Current opinion in plant biology · 2020Review
- Genome-Wide Analysis Reveals Dynamic Epigenomic Differences in Soybean Response to Low-Phosphorus Stress.International journal of molecular sciences · 2020Article
- DNA methylation analysis in plants: review of computational tools and future perspectives.Briefings in bioinformatics · 2020Review
- Active DNA Demethylation in Plants.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation in plants plays a role in transposon silencing, genome stability and gene expression regulation. Environmental factors alter the methylation pattern of DNA and recently nutrient stresses, such as phosphate starvation, were shown to alter DNA methylation. Furthermore, DNA methylation had been frequently addressed in plants with notably small genomes that are poor in transposons. Here, we compare part of the DNA methylome of nitrogen- and phosphorus-deficient maize roots by reduced representation sequencing and analyze their relationship with gene expression under prolonged stresses. Tremendous DNA methylation loss was encountered in maize under nitrogen-deficiency, but much less with phosphorus-deficiency. This occurred only in the symmetrical cytosine context, predominantly in CG context, but also in the CHG context. In contrast to other plants, differential methylation in the more flexible CHH context was essentially absent. In both deficiency conditions a similar number of differentially expressed genes were found and differentially methylated regions (DMRs) were predominantly identified in transposable elements (TEs). A minor fraction of such DMRs was associated with altered gene expression of nearby genes. Interestingly, although these TEs were mostly hypomethylated, they were associated with both up- or down regulated gene expression. Our results suggest a different methylome regulation in maize compared to rice and Arabidopsis upon nutrient deficiencies and point to highly nutrient- and species-specific dynamics of genomic DNA methylation.
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Registered trials
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