Evidence map›Paper›PMID 29725320›Full record

ArticleFrontiers in endocrinology2018

Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association?

Szabolcs Nyiraty, Fruzsina Pesei, Andrea Orosz, Sara Coluzzi, Orsolya Eszter Vági, Csaba Lengyel, György Ábrahám, Simona Frontoni, Peter Kempler, Tamás Várkonyi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  10. Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2022
    Review
  11. Review
  12. The Emerging Role of Continuous Glucose Monitoring in the Management of Diabetic Peripheral Neuropathy: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Szabolcs NyiratyFirst Department of Medicine, University of Szeged, Szeged, Hungary.
Fruzsina PeseiFirst Department of Medicine, University of Szeged, Szeged, Hungary.
Andrea OroszDepartment of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.
Sara ColuzziDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Orsolya Eszter VágiFirst Department of Medicine, Semmelweis University, Budapest, Hungary.
Csaba LengyelFirst Department of Medicine, University of Szeged, Szeged, Hungary.
György ÁbrahámFirst Department of Medicine, University of Szeged, Szeged, Hungary.
Simona FrontoniDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Peter KemplerFirst Department of Medicine, Semmelweis University, Budapest, Hungary.
Tamás VárkonyiFirst Department of Medicine, University of Szeged, Szeged, Hungary.
University of Szeged · HUSemmelweis University · HUFatebenefratelli Hospital · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect GV. PATIENTS AND

methodsTwenty type 1 diabetic patients were involved (age: 39.5 ± 3.4 years, duration of diabetes: 17.5 ± 2.5 years; HbA1c: 8.1 ± 0.2%, mean ± SE). AN was assessed by the cardiovascular reflex tests. The interstitial glucose levels were determined following insertion of a subcutaneous electrode during the continuous glucose monitoring (CGM) method on six consecutive days. GV was characterized by calculation of four parameters.

resultsSD of interstitial glucose values correlated positively with the overall AN score and the degree of the orthostatic reduction of systolic blood pressure (AN-score-SD ρ = 0.47,

conclusionSeverity of glucose variability but not overall glucose load correlates with both parasympathetic and sympathetic dysfunctions in type 1 diabetes. Higher HbA1c is associated with more severe glucose variability. The observed correlation between increased glucose variability and the severity of AN necessitates the further exploration of this relationship.

Indexed as

autonomic neuropathycardiovascular reflex testscontinuous glucose monitoringglucose variabilitytype 1 diabetes

Identifiers

PMID29725320
PMCPMC5916962
OpenAlexW2799855872

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.