Evidence map›Paper›PMID 29725274›Full record

ArticleTheScientificWorldJournal2018

HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana.

David Larbi Simpong, Richard Harry Asmah, Cecilia Krampah, Patrick Kafui Akakpo, Patrick Adu, Du-Bois Asante, Simon Naporo, Andrew Anthony Adjei, Richard Kwasi Gyasi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

David Larbi SimpongDepartment of Medical Laboratory Sciences, University of Cape Coast, Cape Coast, Ghana.ORCID 0000-0002-9194-3762
Richard Harry AsmahDepartment of Medical Laboratory Sciences, University of Ghana, Accra, Ghana.
Cecilia KrampahDepartment of Pathology, University of Ghana, Accra, Ghana.
Patrick Kafui AkakpoDepartment of Pathology, University of Ghana, Accra, Ghana.
Patrick AduInstitute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK.ORCID 0000-0002-9686-8300
Du-Bois AsanteDepartment of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, Ghana.ORCID 0000-0001-5207-5942
Simon NaporoDepartment of Pathology, University of Ghana, Accra, Ghana.
Andrew Anthony AdjeiDepartment of Pathology, University of Ghana, Accra, Ghana.
Richard Kwasi GyasiDepartment of Pathology, University of Ghana, Accra, Ghana.
University of Ghana · GHUniversity of Cape Coast · GHUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognosis of gastric and oesophageal adenocarcinoma remains generally poor. However, mounting evidence suggests a positive role of human epidermal growth factor receptor-2 (HER-2) expression in the prognosis of patients with these cancers. In this work, the patterns of HER-2 protein expression were determined in patients with gastric or oesophageal adenocarcinoma. Retrospectively, we reviewed records of gastric and oesophageal biopsies received from 2008 to 2012 and their corresponding archived formalin-fixed paraffin-embedded tissue blocks selected for immunohistochemical analysis. The prevalence of gastric and oesophageal adenocarcinomas and their association with HER-2 protein overexpression were evaluated. Gastric adenocarcinoma made up 18.79% of the gastric biopsies reviewed, and majority of these cancers occurred in males. Regarding the tumour type, HER-2 overexpression was common in the intestinal subtype compared to the diffuse type. Although squamous cell carcinoma was observed to be the commonest (31%) tumour type in the oesophagus compared to adenocarcinoma (8.79%), HER-2 was overexpressed in 42.9% of oesophageal adenocarcinomas, like gastric adenocarcinoma (41.4%). There is a high prevalence of gastric and oesophageal adenocarcinoma, with significant overexpression of HER-2 in these tumours, a window of hope for the management of patients with these cancers.

Indexed as

AdenocarcinomaAdolescentAdultAgedBiomarkers, TumorChildChild, PreschoolErb-b2 Receptor Tyrosine KinasesEsophageal NeoplasmsFemaleGene ExpressionGhanaHumansImmunohistochemistryInfantInfant, NewbornBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine Kinases

Identifiers

PMID29725274
PMCPMC5872623
OpenAlexW2789856243

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.