ArticleChemistry of materials : a publication of the American Chemical Society2017
Peptide-Binding Nanoparticle Materials with Tailored Recognition sites for Basic Peptides.
Article in Chemistry of materials : a publication of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Substrate Protection in Controlled Enzymatic Transformation of Peptides and Proteins.Chembiochem : a European journal of chemical biology · 2021Article
- Sequence-Selective Protection of Peptides from Proteolysis.Angewandte Chemie (International ed. in English) · 2021Article
- Tunable Artificial Enzyme-Cofactor Complex for Selective Hydrolysis of Acetals.The Journal of organic chemistry · 2021Article
- Molecularly Imprinted Micelles for Fluorescent Sensing of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs).Reactive & functional polymers · 2021Article
- Selective Binding of Complex Glycans and Glycoproteins in Water by Molecularly Imprinted Nanoparticles.Nano letters · 2020Article
- Dandelion flower-like micelles.Chemical science · 2019Article
- Zwitterionic Molecularly Imprinted Cross-Linked Micelles for Alkaloid Recognition in Water.The Journal of organic chemistry · 2019Article
- General Method for Peptide Recognition in Water through Bioinspired Complementarity.Chemistry of materials : a publication of the American Chemical Society · 2019Article
- Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors.Chemical communications (Cambridge, England) · 2019Article
- Sequence-Selective Recognition of Peptides in Aqueous Solution: A Supramolecular Approach through Micellar Imprinting.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Selective Binding of Folic Acid and Derivatives by Imprinted Nanoparticle Receptors in Water.Bioconjugate chemistry · 2018Article
- Surface Ligands in the Imprinting and Binding of Molecularly Imprinted Cross-Linked Micelles.Supramolecular chemistry · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Peptides rich in basic residues such as lysine and arginine play important roles in biology such as bacterial defense and cell penetration. Although peptide-binding materials with high sequence-specificity have broad potential applications, the diverse functionalities of peptide side chains make their molecular recognition extremely difficult. By covalently capturing micelles of a doubly cross-linkable surfactant with solubilized peptide templates, we prepared water-soluble molecularly imprinted nanoparticles with high sequence-specificity for basic peptides. The nanoparticles interact with the side chains of lysine and arginine through hydrogen bonds strengthened by the nonpolar environment of the micelle. They have hydrophobic pockets in their core complementary to the hydrophobic side chains in size and shape. These recognition sites allowed the micelles to bind basic biological peptides strongly in water, with tens to hundreds of nanomolar in binding affinity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.