Evidence map›Paper›PMID 29725044›Full record

ArticleNature communications2018

Nuclear fate of yeast snoRNA is determined by co-transcriptional Rnt1 cleavage.

Pawel Grzechnik, Sylwia A Szczepaniak, Somdutta Dhir, Anna Pastucha, Hannah Parslow, Zaneta Matuszek, Hannah E Mischo, Joanna Kufel, Nicholas J Proudfoot

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Small Nucleolar RNA fromNon-coding RNA · 2025
    Article
  7. Review
  8. SnoRNAs: Exploring Their Implication in Human Diseases.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Splicing inactivation generates hybrid mRNA-snoRNA transcripts targeted by cytoplasmic RNA decay.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Emerging Functions for snoRNAs and snoRNA-Derived Fragments.International journal of molecular sciences · 2021
    Review
  16. International journal of molecular sciences · 2021
    Review
  17. Review
  18. Records of RNA locations in living yeast revealed through covalent marks.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Pawel GrzechnikSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK. P.L.Grzechnik@bham.ac.uk.
Sylwia A SzczepaniakInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106, Warsaw, Poland.
Somdutta DhirSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
Anna PastuchaInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106, Warsaw, Poland.
Hannah ParslowSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Zaneta MatuszekInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106, Warsaw, Poland.
Hannah E MischoSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
Joanna KufelInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106, Warsaw, Poland. kufel@ibb.waw.pl.
Nicholas J ProudfootSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK. nicholas.proudfoot@path.ox.ac.uk.
University of Oxford · GBUniversity of Warsaw · PLCollege of Europe, Warsaw · PLUniversity of Birmingham · GB

Funding

European Research Council 339270Wellcome Trust
6 · The paper itself

Abstract

Small nucleolar RNA (snoRNA) are conserved and essential non-coding RNA that are transcribed by RNA Polymerase II (Pol II). Two snoRNA classes, formerly distinguished by their structure and ribonucleoprotein composition, act as guide RNA to target RNA such as ribosomal RNA, and thereby introduce specific modifications. We have studied the 5'end processing of individually transcribed snoRNA in S. cerevisiae to define their role in snoRNA biogenesis and functionality. Here we show that pre-snoRNA processing by the endonuclease Rnt1 occurs co-transcriptionally with removal of the m

Indexed as

Cell NucleusCytoplasmMethylationRibonuclease IIIRibonucleoproteins, Small NucleolarRNA CapsRNA, FungalRNA Processing, Post-TranscriptionalRNA, Small NucleolarSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsRibonuclease IIIRibonucleoproteins, Small NucleolarRNA CapsRNA, FungalRNA, Small NucleolarRNT1 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID29725044
PMCPMC5934358
OpenAlexW2802175426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.