ArticleScientific reports2018
Facial bone fragmentation in blind cavefish arises through two unusual ossification processes.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Loss of Conserved Noncoding Elements Likely Shaped the Evolution of Regressed Phenotypes in Cavefish.Genome biology and evolution · 2025Article
- Sensory evolution in a cavefish radiation: patterns of neuromast distribution and associated behaviour inProceedings. Biological sciences · 2022Article
- Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- An Asymmetric Genetic Signal Associated with Mechanosensory Expansion in Cave-Adapted Fish.Symmetry · 2020Article
- Parallel evolution of regressive and constructive craniofacial traits across distinct populations of Astyanax mexicanus cavefish.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2020Article
- Dark world rises: The emergence of cavefish as a model for the study of evolution, development, behavior, and disease.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2020Article
- Maternal genetic effects in Astyanax cavefish development.Developmental biology · 2018Article
- Morphology and life history divergence in cave and surface populations of Gammarus lacustris (L.).PloS one · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The precise mechanisms underlying cranial bone development, evolution and patterning remain incompletely characterised. This poses a challenge to understanding the etiologies of craniofacial malformations evolving in nature. Capitalising on natural variation, "evolutionary model systems" provide unique opportunities to identify underlying causes of aberrant phenotypes as a complement to studies in traditional systems. Mexican blind cavefish are a prime evolutionary model for cranial disorders since they frequently exhibit extreme alterations to the skull and lateral asymmetries. These aberrations occur in stark contrast to the normal cranial architectures of closely related surface-dwelling fish, providing a powerful comparative paradigm for understanding cranial bone formation. Using a longitudinal and in vivo analytical approach, we discovered two unusual ossification processes in cavefish that underlie the development of 'fragmented' and asymmetric cranial bones. The first mechanism involves the sporadic appearance of independent bony elements that fail to fuse together later in development. The second mechanism involves the "carving" of channels in the mature bone, a novel form of post-ossification remodeling. In the extreme cave environment, these novel mechanisms may have evolved to augment sensory input, and may indirectly result in a trade-off between sensory expansion and cranial bone development.
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