Evidence map›Paper›PMID 29724910›Full record

ArticleJournal of cell science2018

Retromer associates with the cytoplasmic amino-terminus of polycystin-2.

Frances C Tilley, Matthew Gallon, Chong Luo, Chris M Danson, Jing Zhou, Peter J Cullen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Frances C TilleySchool of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.ORCID 0000-0002-6021-4989
Matthew GallonSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.
Chong LuoHarvard Center for Polycystic Kidney Disease Research and Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chris M DansonSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.
Jing ZhouHarvard Center for Polycystic Kidney Disease Research and Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Peter J CullenSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK pete.cullen@bristol.ac.uk.ORCID 0000-0002-9070-8349
University of Bristol · GBBrigham and Women's Hospital · US

Funding

Pilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI TORRES, VICENTE E · 2010 to 2019
$11.8M
Cell biology of autosomal dominant polycystic kidney diseaseR01DK099532 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, JING · 2014 to 2016
$796k
Medical Research Council MR/L007363/1Medical Research Council MR/P018807/1NIDDK NIH HHS P30 DK090728NIDDK NIH HHS R01 DK099532Wellcome Trust 089928Wellcome Trust 104568/Z/14/Z
6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic human disease, with around 12.5 million people affected worldwide. ADPKD results from mutations in either

Indexed as

Amino Acid MotifsAnimalsEndosomesGene Knockout TechniquesHEK293 CellsHeLa CellsHumansMiceMultiprotein ComplexesPolycystic Kidney, Autosomal DominantProtein Interaction Domains and MotifsTRPP Cation ChannelsMultiprotein ComplexesTRPP Cation ChannelsEndosomePolycystin-2Retromer

Identifiers

PMID29724910
PMCPMC6031323
OpenAlexW2800284835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.