Evidence map›Paper›PMID 29724905›Full record

ArticleScience (New York, N.Y.)2018

Gut microbiota utilize immunoglobulin A for mucosal colonization.

G P Donaldson, M S Ladinsky, K B Yu, J G Sanders, B B Yoo, W-C Chou, M E Conner, A M Earl, R Knight, P J Bjorkman and 1 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 361 papers.

0numbers the graph read from it
0cells of the map it votes in
361citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

361 citing papers in PubMed.

  1. Trial
  2. Review
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  6. Soluble Dietary Fiber fromInternational journal of molecular sciences · 2026
    Article
  7. Review
  8. Review
  9. Article
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  14. Review
  15. Characterization of aFrontiers in cellular and infection microbiology · 2026
    Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

301 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

G P DonaldsonDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. gdonalds@caltech.edu sarkis@caltech.edu.ORCID 0000-0002-8551-374X
M S LadinskyDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-1036-3513
K B YuDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0001-6735-3968
J G SandersDepartment of Pediatrics, University of California, San Diego, CA 92110, USA.ORCID 0000-0001-6077-4014
B B YooDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
W-C ChouInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-8408-3533
M E ConnerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-7146-8159
A M EarlInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-7857-9145
R KnightDepartment of Pediatrics, University of California, San Diego, CA 92110, USA.ORCID 0000-0002-0975-9019
P J BjorkmanDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-2277-3990
S K MazmanianDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. gdonalds@caltech.edu sarkis@caltech.edu.ORCID 0000-0003-2713-1513

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI SABETI, PARDIS CHRISTINE · 2014 to 2024
$66.5M
X-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
Protection from Mucosal Pathology by Gut Microflora during Experimental ColitisR01DK078938 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2009 to 2020
$5.1M
LYMPHOEPITHELIAL INTERACTION DURING CHLAMYDIAL INFECTIONR01AI041231 · NIAID · MOREHOUSE SCHOOL OF MEDICINE · PI EKO, FRANCIS O. · 1996 to 2014
$3.8M
NEONATAL FC RECEPTOR/IGG INTERACTIONR01AI041239 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BJORKMAN, PAMELA J · 1997 to 2018
$2.3M
Molecular Mechanisms that Shape Gut Microbial CommunitiesR01GM099535 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2012 to 2015
$1.6M
Identification of Bacteroides Fragilis Colonization during Host MutualismR21DK083633 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2010 to 2011
$444k
NIAID NIH HHS R01 AI041231NIAID NIH HHS R01 AI041239NIAID NIH HHS U19 AI110818NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK078938NIDDK NIH HHS R21 DK083633NIGMS NIH HHS P50 GM082545NIGMS NIH HHS R01 GM099535NIGMS NIH HHS T32 GM007616
6 · The paper itself

Abstract

The immune system responds vigorously to microbial infection while permitting lifelong colonization by the microbiome. Mechanisms that facilitate the establishment and stability of the gut microbiota remain poorly described. We found that a regulatory system in the prominent human commensal

Indexed as

AnimalsBacterial AdhesionBacterial ProteinsBacteroides fragilisCells, CulturedGastrointestinal MicrobiomeHumansImmunoglobulin AIntestinal MucosaMicePolysaccharides, BacterialSymbiosisBacterial ProteinsImmunoglobulin APolysaccharides, Bacterial

Identifiers

PMID29724905
PMCPMC5973787

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.