Evidence map›Paper›PMID 29724824›Full record

ArticleThe Journal of biological chemistry2018

Distinctive phosphoinositide- and Ca

Mareike G Posner, Abhishek Upadhyay, Rieko Ishima, Antreas C Kalli, Gemma Harris, Joachim Kremerskothen, Mark S P Sansom, Susan J Crennell, Stefan Bagby

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Binding of CaStructure (London, England : 1993) · 2021
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Mareike G PosnerFrom the Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.
Abhishek UpadhyayFrom the Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.
Rieko IshimaDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.
Antreas C KalliLeeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
Gemma HarrisResearch Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0FA, United Kingdom.
Joachim KremerskothenInternal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Münster, D-48149 Münster, Germany, and.
Mark S P SansomDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Susan J CrennellFrom the Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.
Stefan BagbyFrom the Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom, bsssb@bath.ac.uk.ORCID 0000-0003-2302-9511
University of Bath · GBRutherford Appleton Laboratory · GBUniversity Hospital Münster · DEUniversity of Leeds · GBUniversity of Oxford · GBUniversity of Pittsburgh · US

Funding

Biotechnology and Biological Sciences Research Council BB/J008176/1Medical Research Council MC_U117533887
6 · The paper itself

Abstract

Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking. KIBRA includes tandem N-terminal WW domains, a C2 domain, and motifs for binding atypical PKC and PDZ domains. A naturally occurring human KIBRA variant involving residue changes at positions 734 (Met-to-Ile) and 735 (Ser-to-Ala) within the C2 domain affects cognitive performance. We have elucidated 3D structures and calcium- and phosphoinositide-binding properties of human KIBRA C2 domain. Both WT and variant C2 adopt a canonical type I topology C2 domain fold. Neither Ca

Indexed as

C2 DomainsCalciumCell MembraneCrystallography, X-RayHumansIntracellular Signaling Peptides and ProteinsModels, MolecularPhosphatidylinositolsPhosphoproteinsPolymorphism, Single NucleotideProtein BindingProtein ConformationCalciumIntracellular Signaling Peptides and ProteinsPhosphatidylinositolsPhosphoproteinsWWC1 protein, humanAlzheimer diseaseanalytical ultracentrifugationC2 domaincalcium-binding proteincrystallographyHippo pathwayhuman cognitionKIBRAmembrane traffickingmolecular dynamicsnuclear magnetic resonance (NMR)phosphoinositideWWC protein familyα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor, AMPAR)

Identifiers

PMID29724824
PMCPMC6005455
OpenAlexW2795818086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.