Evidence map›Paper›PMID 29724779›Full record

ArticleJournal of lipid research2018

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A

Vania Hinkovska-Galcheva, Robert Kelly, Kelly A Manthei, Renee Bouley, Wenmin Yuan, Anna Schwendeman, John J G Tesmer, James A Shayman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Activity-Based Acylome Profiling withJournal of the American Chemical Society · 2024
    Article
  6. Article
  7. Article
  8. Lysosomal phospholipase A2.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vania Hinkovska-GalchevaDepartment of Internal Medicine, University of Michigan Medical School, University of Michigan, Ann Arbor, MI.ORCID 0000-0001-8562-9913
Robert KellyDepartment of Internal Medicine, University of Michigan Medical School, University of Michigan, Ann Arbor, MI.
Kelly A MantheiLife Sciences Institute and the Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI.
Renee BouleyLife Sciences Institute and the Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI.
Wenmin YuanDepartment of Pharmaceutical Science, Biointerfaces Institute, University of Michigan, Ann Arbor, MI.
Anna SchwendemanDepartment of Pharmaceutical Science, Biointerfaces Institute, University of Michigan, Ann Arbor, MI.
John J G TesmerLife Sciences Institute and the Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-1125-3727
James A ShaymanDepartment of Internal Medicine, University of Michigan Medical School, University of Michigan, Ann Arbor, MI jshayman@umich.edu.

Funding

Structure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1M
Structure and Function of the LPLA2/LCAT Acyltransferase FamilyR01HL122416 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TESMER, JOHN · 2015 to 2018
$1.9M
Lysosomal Phospholipase A2 in Autoimmune DiseaseR01AR056991 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAYMAN, JAMES ALAN · 2010 to 2014
$1.6M
Structural and functional studies of lecithin:cholesterol acyltransferaseF32HL131288 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MANTHEI, KELLY A · 2016 to 2018
$179k
Mechanisms of Drug Induced PhospholipidosisI01BX002021 · VA · VETERANS HEALTH ADMINISTRATION · PI SHAYMAN, JAMES ALAN · 2013 to 2016
–
BLRD VA I01 BX002021NHLBI NIH HHS F32 HL131288NHLBI NIH HHS R01 HL071818NHLBI NIH HHS R01 HL122416NIAMS NIH HHS R01 AR056991
6 · The paper itself

Abstract

Lysosomal phospholipase A2 (LPLA

Indexed as

AcylationHumansHydrogen-Ion ConcentrationHydrolysisLysosomesModels, MolecularMutationPhospholipases A2Protein Structure, TertiarySubstrate SpecificityPhospholipases A21-O-acylceramideacyltransferaseceramidecholesterolcrystallographylysosomepH dependencephospholipase A2 group XVselectivity

Identifiers

PMID29724779
PMCPMC6027918

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.