ArticleCirculation. Heart failure2018
Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support.
Article in Circulation. Heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Microcirculation and Cerebrovascular Autoregulation in Patients With Mechanical Circulatory Support Devices.Journal of stroke · 2026Review
- Hemodynamic analysis of the aortic root based on differences in outflow graft angle in patients with implantable left ventricular assist devices.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Article
- Physiologic effects of different hemodynamic patterns of LVAD.Frontiers in cardiovascular medicine · 2025Review
- Animal Models for Mechanical Circulatory Support: A Research Review.Reviews in cardiovascular medicine · 2024Review
- Interplay between driveline infection, vessel wall inflammation, cerebrovascular events and mortality in patients with left ventricular assist device.Scientific reports · 2023Article
- A sensorless, physiologic feedback control strategy to increase vascular pulsatility for rotary blood pumps.Biomedical signal processing and control · 2023Article
- Review
- Cardiac mechanics and reverse remodelling under mechanical support from left ventricular assist devices.Frontiers in cardiovascular medicine · 2023Review
- Intracellular CaJournal of cardiovascular translational research · 2022Article
- Matrix-Degrading Enzyme Expression and Aortic Fibrosis During Continuous-Flow Left Ventricular Mechanical Support.Journal of the American College of Cardiology · 2021Article
- Reverse Remodeling With Left Ventricular Assist Devices.Circulation research · 2021Review
- Effects of Pulsatile Frequency of Left Ventricular Assist Device (LVAD) on Coronary Perfusion: A Numerical Simulation Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Imaging tools for assessment of myocardial fibrosis in humans: the need for greater detail.Biophysical reviews · 2020Review
- Triptolide Attenuates Transplant Vasculopathy Through Multiple Pathways.Frontiers in immunology · 2020Article
- Living Without a Pulse: The Vascular Implications of Continuous-Flow Left Ventricular Assist Devices.Circulation. Heart failure · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCoronary artery fluid dynamics may be altered because of the nonphysiological flow seen in continuous-flow left ventricular assist devices (CF-LVADs). Our aim was to study the structure and composition of coronary vessels after CF-LVAD. METHODS AND
resultsCoronary arteries were collected from patients with heart failure (HF) at the time of transplantation, of whom 15 were supported with a CF-LVAD before transplant (HF+LVAD group) and 9 were not (HF non-LVAD group). In addition, coronary samples were obtained from 5 nonfailing age-matched donors (nonfailing group). Histological analysis was performed to quantify coronary morphology, composition, vascular fibrosis, and vasa vasorum density. The age and sex mix of the 3 groups were similar, and the mean duration of LVAD support was 213 days. Compared with patients with HF and nonfailing donors, the arteries from patients with HF+LVAD had expansion of the adventitia, breakdown of the internal elastic lamina, and increased adventitial collagen deposition and density of vasa vasorum.
conclusionsAmong patients supported with CF-LVADs, the coronary arteries develop marked remodeling with increased adventitial fibrosis. The physiological consequences of these structural changes are unknown, but it is possible that arterial contractility may be impaired, thus limiting coronary flow reserve and promoting myocardial ischemia. This may contribute to CF-LVAD complications, such as ventricular arrhythmias and right ventricular failure. As more patients receive CF-LVADs and new pump technology attempts to modulate flow profiles and pulsatility, further research is needed to understand the mechanisms and long-term sequela of these changes in coronary arteries and other vascular beds.
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Registered trials
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