ArticleCancer research2018
Open access · greenAbstract read
In one paragraph
Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
- Genomic context of mutations in MIR142 in blood cancers: summary and integrative analysis.Cellular & molecular biology letters · 2026Review
- Allosteric inhibition of RAN decreases miR-126 biogenesis in endothelial cells and controls acute myeloid leukemia growth.Communications biology · 2026Article
- miRNA gene mutations commonly disrupt the proper functioning of miRNA genes.Science advances · 2026Article
- Balancing inflammatory signaling in hematopoiesis: roles of MIRC11 and miR-146a.Frontiers in immunology · 2026Article
- Comprehensive multi-omics analysis of histone acetylation modulators identifies ASH1L as a novel aggressive marker for osteosarcoma.Discover oncology · 2025Article
- The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers.Science advances · 2025Article
- miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape.Nature communications · 2025Article
- Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors.Journal of medicinal chemistry · 2025Article
- Loss-of-function mutations of microRNA-142-3p promoteWorld journal of gastroenterology · 2025Article
- MicroRNA-focused CRISPR/Cas9 screen identifies miR-142 as a key regulator of Epstein-Barr virus reactivation.PLoS pathogens · 2024Article
- The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis.Cell death and differentiation · 2024Article
- miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities.Cells · 2023Review
- MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications.Biomolecules · 2023Review
- Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis.Nature communications · 2023Article
- Genomic landscapes of ovarian clear cell carcinoma from latin countries reveal aberrations linked to survival and progression.BMC cancer · 2023Article
- A gain-of-function mutation in microRNA 142 is sufficient to cause the development of T-cell leukemia in mice.Cancer science · 2023Article
- Comparative miRNA expression profile analysis of porcine ovarian follicles: new insights into the initiation mechanism of follicular atresia.Frontiers in genetics · 2023Article
- Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia.Frontiers in oncology · 2023Review
- Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Maria C Trissal *Division of Oncology, Washington University School of Medicine, St. Louis, Missouri.
Terrence N Wong *Division of Oncology, Washington University School of Medicine, St. Louis, Missouri.
Juo-Chin Yao *Division of Oncology, Washington University School of Medicine, St. Louis, Missouri.ORCID 0000-0002-2041-9867
Rahul RamaswamyDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri.
Iris KuoDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri.
Jack BatyDivision of Biostatistics, Washington University, St. Louis, Missouri.
Yaping SunDivision of Hematology-Oncology, University of Michigan, Ann Arbor, Michigan.
Gloria JihLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Nishi ParikhLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Melissa M Berrien-ElliottDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri.
Todd A FehnigerDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri.
Timothy J LeyDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri.
Ivan MaillardDivision of Hematology-Oncology, University of Michigan, Ann Arbor, Michigan.
Pavan R ReddyDivision of Hematology-Oncology, University of Michigan, Ann Arbor, Michigan.
Daniel C LinkDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri. danielclink@wustl.edu.
Washington University in St. Louis · USUniversity of Michigan · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MSpecimen Acquistition and Expression ProfilingP01CA101937 · NCI · WASHINGTON UNIVERSITY · PI LINK, DANIEL C · 2003 to 2023
$58.8MTargeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI Daniel C Link · 2013 to 2026
$31.6MPRE-AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGYT32HL007088 · NHLBI · WASHINGTON UNIVERSITY · PI Grant Anthony Challen, Stephen Oh · 1985 to 2026
$14.1MMolecular Pathogenesis of Acute Myeloid LeukemiaR35CA197561 · NCI · WASHINGTON UNIVERSITY · PI Timothy J. Ley · 2015 to 2026
$11.0MTRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9MMOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7MCLINICAL HEMATOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM AT WASHINGTON UNIVERSITYK12HL087107 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2006 to 2016
$3.8MTRANSLATING NK CELL BIOLOGY INTO CLINICAL CANCER IMMUNOTHERAPYR01CA205239 · NCI · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2017 to 2020
$2.4MMolecular functions of the shelterin component ACD/TPP1 in somatic stem cells and tissue homeostasisR01AG050509 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEGAN, CATHERINE ELIZABETH, MAILLARD, IVAN · 2015 to 2019
$2.3MCLONAL DOMINANCE OF HEMATOPOIETIC STEM CELLS EXPRESSING MUTANT CSF3RR01CA136617 · NCI · WASHINGTON UNIVERSITY · PI LINK, DANIEL C · 2009 to 2013
$1.5MMICRORNA REGULATION OF NK CELL DEVELOPMENT AND FUNCTIONR01AI102924 · NIAID · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2013 to 2016
$1.5MNCI NIH HHS F32 CA200253NCI NIH HHS K08 CA197369NCI NIH HHS P01 CA101937NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA171963NCI NIH HHS R01 CA136617NCI NIH HHS R01 CA205239NCI NIH HHS R35 CA197561NCI NIH HHS T32 CA113275NHLBI NIH HHS K12 HL087107NIAID NIH HHS R01 AI102924NIA NIH HHS R01 AG050509NICHD NIH HHS T32 HD007505
Abstract
Point mutations in the seed sequence of miR-142-3p are present in a subset of acute myelogenous leukemia (AML) and in several subtypes of B-cell lymphoma. Here, we show that mutations associated with AML result both in loss of miR-142-3p function and in decreased miR-142-5p expression.
Indexed as
Gene Expression Regulation, LeukemicAnimalsBone MarrowCarcinogenesisDisease Models, AnimalDNA-Binding ProteinsHEK293 CellsHematopoietic Stem CellsHistone-Lysine N-MethyltransferaseHomeobox A10 ProteinsHomeodomain ProteinsHumansIsocitrate DehydrogenaseLeukemia, Myeloid, AcuteLoss of Function MutationMiceASH1L protein, humanAsh1l protein, mouseDNA-Binding ProteinsEPHB2 protein, humanHistone-Lysine N-MethyltransferaseHomeobox A10 Proteinshomeobox protein HOXA9Homeodomain ProteinsHOXA10 protein, humanHoxa10 protein, mouseIDH2 protein, humanIsocitrate DehydrogenaseMicroRNAsMIRN142 microRNA, humanMirn142 microRNA, mouseReceptor, EphB2Transcription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.