ArticleAnnals of epidemiology2018
The role of parental and perinatal characteristics on Langerhans cell histiocytosis: characterizing increased risk among Hispanics.
Article in Annals of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Patients with langerhans cell histiocytosis and hypothalamic-pituitary involvement: insights from the HEROS study cohort.Pituitary · 2025Observational
- Unraveling the Genetic Landscape of Langerhans Cell Histiocytosis in Korean Patients: Comprehensive Insights from Mutational Profiles and Clinical Correlations.Cancer research and treatment · 2025Article
- Maternal Herpes Zoster Infection Preceding Neonatal Langerhans Cell Histiocytosis: Coincidence or Association?Cureus · 2024Article
- Article
- Clinical features and prognostic factors of pediatric Langerhans cell histiocytosis: a single-center retrospective study.Frontiers in medicine · 2024Article
- Langerhans cell histiocytosis: unusual bone marrow infiltration-report of 2 cases in Ecuador.Frontiers in medicine · 2024Article
- Incidence, prevalence and survival in patients with Langerhans cell histiocytosis: A national registry study from England, 2013-2019.British journal of haematology · 2022Article
- Langerhans Cell Histiocytosis: A Population-based Study of Anatomical Distribution and Treatment Patterns.Journal of bone oncology · 2022Article
- Educational Case: Langerhans cell histiocytosis.Academic pathology · 2022Article
- Histiocytic disorders.Nature reviews. Disease primers · 2021Review
- Childhood Langerhans cell histiocytosis: a disease with many faces.World journal of pediatrics : WJP · 2019Review
- Maternal Residential Proximity to Major Roadways and the Risk of Childhood Acute Leukemia: A Population-Based Case-Control Study in Texas, 1995-2011.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposePotential roles of inherited and environmental risk factors in pathogenesis of Langerhans cell histiocytosis (LCH), a myeloid neoplastic disorder, are undefined. We therefore evaluated the role of parental and perinatal factors on the risk of this childhood cancer.
methodsInformation on LCH cases (n = 162) for the period 1995-2011 was obtained from the Texas Cancer Registry. Birth certificate controls were frequency-matched on year of birth at a ratio of 10:1 for the same period. Variables evaluated included parental age, race/ethnicity, size for gestational age, and birth order. Logistic regression was used to generate an adjusted odds ratio (aOR) and 95% confidence interval (CI) testing the association between each factor and LCH.
resultsFew perinatal or parental factors were associated with LCH risk, with the exception of race/ethnicity. Mothers of Hispanic ethnicity were more likely to have children who developed LCH compared to non-Hispanic whites (aOR: 1.51; 95% CI: 1.02-2.25). This risk increased when both parents were Hispanic (aOR: 1.80; 95% CI: 1.13-2.87). Non-Hispanic black mothers were suggested as less likely to give birth to offspring who developed LCH compared to non-Hispanic whites (aOR: 0.50; 95% CI: 0.24-1.02).
conclusionsLCH is characterized by somatic mutations in MAPK pathway genes in myeloid precursors. Increased risk for LCH in children of Hispanic parents suggests potential impact of inherited factors on LCH pathogenesis.
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