Evidence map›Paper›PMID 29724240›Full record

ArticleJournal of neuroinflammation2018

Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice.

Zhuo Cheng, Liping Wang, Meijie Qu, Huaibin Liang, Wanlu Li, Yongfang Li, Lidong Deng, Zhijun Zhang, Guo-Yuan Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.

  1. [Research progress of different types of stem cells in treatment of ischemic stroke].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021
    Pooled it
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  11. The blood-brain barrier: a help and a hindrance.Brain : a journal of neurology · 2025
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhuo ChengSchool of Biomedical Engineering and Shanghai Jiao Tong University affiliated sixth people's hospital, Shanghai Jiao Tong University, Shanghai, 200000, China.
Liping WangDepartment of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Meijie QuDepartment of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Huaibin LiangDepartment of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Wanlu LiSchool of Biomedical Engineering and Shanghai Jiao Tong University affiliated sixth people's hospital, Shanghai Jiao Tong University, Shanghai, 200000, China.
Yongfang LiDepartment of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Lidong DengSchool of Biomedical Engineering and Shanghai Jiao Tong University affiliated sixth people's hospital, Shanghai Jiao Tong University, Shanghai, 200000, China.
Zhijun ZhangSchool of Biomedical Engineering and Shanghai Jiao Tong University affiliated sixth people's hospital, Shanghai Jiao Tong University, Shanghai, 200000, China.
Guo-Yuan YangSchool of Biomedical Engineering and Shanghai Jiao Tong University affiliated sixth people's hospital, Shanghai Jiao Tong University, Shanghai, 200000, China. gyyang@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-3105-9307
Shanghai Jiao Tong University · CN

Funding

National Key Research and Development Program of China 2016YFC1300600National Natural Science Foundation of China 81471178National Natural Science Foundation of China 81771244National Natural Science Foundation of China 81771251Science and Technology Commission of Shanghai Municipality 17ZR1413600
6 · The paper itself

Abstract

backgroundIschemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unknown. We therefore hypothesized that mesenchymal stem cells reduced blood-brain barrier destruction by inhibiting matrixmetallo-proteinase-9 and it was related to intercellular adhesion molecule-1 (ICAM-1).

methodsAdult ICR male mice (n = 118) underwent 90-min middle cerebral artery occlusion and received 2 × 10

resultsWe found that intracranial injection of mesenchymal stem cells reduced infarct volume and improved behavioral function in experimental stroke models (p < 0.05). IgG leakage, tight junction protein loss, and inflammatory cytokines IL-1β, IL-6, and TNF-α reduced in mesenchymal stem cell-treated mice compared to the control group following ischemia (p < 0.05). After transplantation, MMP-9 was decreased in protein and activity levels as compared with controls (p < 0.05). Furthermore, myeloperoxidase-positive cells and myeloperoxidase activity were decreased in mesenchymal stem cell-treated mice (p < 0.05).

conclusionThe results showed that mesenchymal stem cell therapy attenuated blood-brain barrier disruption in mice after ischemia. Mesenchymal stem cells attenuated the upward trend of MMP-9 and potentially via downregulating ICAM-1 in endothelial cells. Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway may influence MMP-9 expression of neutrophils and resident cells, and ICAM-1 acted as a key factor in the paracrine actions of mesenchymal stem cell.

Indexed as

AnimalsBlood-Brain BarrierBrain IschemiaCells, CulturedMaleMatrix Metalloproteinase 9Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationMiceMice, Inbred ICRRatsRats, Sprague-DawleyMatrix Metalloproteinase 9Mmp9 protein, mouseBlood-brain barrierICAM-1InflammationIschemiaMatrixmetallo-proteinase-9Mesenchymal stem cell

Identifiers

PMID29724240
PMCPMC5932816
OpenAlexW2800929954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.