ReviewMolecules (Basel, Switzerland)2018
Essential Oils and Their Constituents Targeting the GABAergic System and Sodium Channels as Treatment of Neurological Diseases.
Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis.Frontiers in public health · 2023Pooled it
- Aromatherapy with inhalation effectively alleviates the test anxiety of college students: A meta-analysis.Frontiers in psychology · 2022Pooled it
- Lavender-Neroli Aromatherapy for Reducing Dental Anxiety and Pain in Children During Anesthesia: A Two-Arm Randomized Controlled Trial.Medical sciences (Basel, Switzerland) · 2025Trial
- Integrated Chemical, In Silico, and Functional Neurobehavioral Evaluation of Three Essential Oils in Acute Anxiety- and Depression-Related Mouse Models.Molecules (Basel, Switzerland) · 2026Article
- Chemical Profile and Bioinsecticidal Nanoemulsion ofPlants (Basel, Switzerland) · 2026Article
- Vagal nerve TRPV3 regulates sedative-mediated appeasement.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Insecticidal Potential ofInsects · 2026Article
- Camphor-Induced Seizures in Rats Increase the Potency of Gamma Oscillations During the Ictal Period, A Component that may Lead to Refractoriness in Seizure Control.Neurotoxicity research · 2026Article
- Harnessing phytochemicals for engineering health solutions.Human genomics · 2026Review
- Melissa officinalis essential oil modulates oxidative balance, cholinergic activity, and cognitive performance in a scopolamine-induced zebrafish model: implications for neuroprotective strategies in cognitive disorders.Scientific reports · 2025Article
- Pharmacological and Therapeutic Potential ofBiomolecules · 2025Review
- Anti-Anxiety Effects of Essential Oil Microemulsion in Chronic Unpredictable Mild Stress-Induced Rats: Preparation, Characterization, and Mechanisms.Molecules (Basel, Switzerland) · 2025Article
- Targeting the Gut-Brain Axis with Plant-Derived Essential Oils: Phytocannabinoids and Beyond.Nutrients · 2025Review
- Unraveling the Neuropharmacological Properties ofPharmaceuticals (Basel, Switzerland) · 2025Review
- Essential Oil Constituents as Anti-Inflammatory and Neuroprotective Agents: An Insight through Microglia Modulation.International journal of molecular sciences · 2024Review
- Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis.Current issues in molecular biology · 2024Review
- Essential oil supplementation improves insulin sensitivity and modulates the plasma metabolome of hyperinsulinemic horses.Frontiers in veterinary science · 2024Article
- Anxiety-Reducing Effects of Lavender Essential Oil Inhalation: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties.BMC complementary medicine and therapies · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Essential oils and the constituents in them exhibit different pharmacological activities, such as antinociceptive, anxiolytic-like, and anticonvulsant effects. They are widely applied as a complementary therapy for people with anxiety, insomnia, convulsion, pain, and cognitive deficit symptoms through inhalation, oral administration, and aromatherapy. Recent studies show that essential oils are emerging as a promising source for modulation of the GABAergic system and sodium ion channels. This review summarizes the recent findings regarding the pharmacological properties of essential oils and compounds from the oils and the mechanisms underlying their effects. Specifically, the review focuses on the essential oils and their constituents targeting the GABAergic system and sodium channels, and their antinociceptive, anxiolytic, and anticonvulsant properties. Some constituents target transient receptor potential (TRP) channels to exert analgesic effects. Some components could interact with multiple therapeutic target proteins, for example, inhibit the function of sodium channels and, at the same time, activate GABA
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.