Evidence map›Paper›PMID 29723863›Full record

ArticleCardiorenal medicine2018

Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease.

Antonio Concistrè, Luigi Petramala, Gianmarco Scoccia, Susanna Sciomer, Valeria Bisogni, Vincenza Saracino, Gino Iannucci, Silvia Lai, Daniela Mastroluca, Gianluca Iacobellis and 1 more

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In one paragraph

Article in Cardiorenal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Antonio ConcistrèUnit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Luigi PetramalaUnit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Gianmarco ScocciaUnit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Susanna SciomerDepartment of Cardiovascular and Respiratory Sciences, Sapienza University of Rome, Rome, Italy.
Valeria BisogniUnit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Vincenza SaracinoUnit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Gino IannucciUnit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Silvia LaiDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Daniela MastrolucaNephrology and Dialysis Unit, Hospital ICOT Latina, Sapienza University of Rome, Rome, Italy.
Gianluca IacobellisDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Claudio LetiziaUnit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAutosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown.

aimswe sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH.

methodsWe performed ultrasound measurement of EAT thickness, LVM, LVMi, and left atrium size (left atrial volume indexed for body surface, LAVI) in 41 consecutive hypertensive patients with ADPKD, compared to 89 EH patients.

resultsEAT was significantly higher in the ADPKD group in comparison to EH subjects (9.2 ± 2.9 mm vs. 7.8 ± 1.6 mm, p < 0.001), and significantly correlated with LVM, LVMi, and LAVI in the ADPKD group (r = 0.56, p = 0.005; r = 0.424, p = 0.022; and r = 0.48, p = < 0.001, respectively). Comparing EAT against body mass index, systolic blood pressure, and age, we found that EAT was the strongest predictor of LVMi (β = 0.42, p = 0.007).

conclusionOur data showed that EAT was higher in ADPKD patients than in EH subjects and independently correlated with LVMi. EAT measurement can be a useful marker for the cardiovascular risk stratification in ADPKD.

Indexed as

Adipose TissueAdultAgedAge FactorsBlood PressureBody Mass IndexEchocardiographyEssential HypertensionFemaleHeart AtriaHeart VentriclesHumansMaleMiddle AgedPericardiumPolycystic Kidney, Autosomal DominantAutosomal dominant polycystic kidney diseaseCardiovascular diseaseEpicardial fat thicknessLeft ventricular hypertrophy

Identifiers

PMID29723863
PMCPMC6167706
OpenAlexW2799410345

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.