Evidence map›Paper›PMID 29723497›Full record

ArticleNeuron2018

Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions.

Michel Engeln, Megan E Fox, Mary Kay Lobo

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Accumbal Adenosine AFrontiers in cellular neuroscience · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Michel EngelnDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Megan E FoxDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Mary Kay LoboDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: mklobo@som.umaryland.edu.

Funding

Cocaine-induced mitochondrial mechanisms and molecular mediators in reward circuitryR01DA038613 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LOBO, MARY KAY · 2014 to 2025
$4.9M
molecular mechanisms of dendritic remodeling in depressionF32MH116574 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI FOX, MEGAN ELIZABETH · 2018 to 2020
$188k
NIDA NIH HHS R01 DA038613NIMH NIH HHS F32 MH116574
6 · The paper itself

Abstract

Striatal dopamine signaling is differentially regulated along the dorso-ventral axis, but how these differences are encoded by dopamine receptors is unknown. In this issue of Neuron, Marcott et al. (2018) show that dopamine activates D2 receptors in regionally distinct ways and dissect the underlying mechanisms behind striatal D2 heterogeneity.

Indexed as

DopamineNucleus AccumbensCorpus StriatumNeuronsReceptors, Dopamine D2DopamineReceptors, Dopamine D2addictionD2 receptorsdopaminedorsal striatumnucleus accumbensParkinson’s diseaseschizophrenia

Identifiers

PMID29723497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.