SynthesisClinics (Sao Paulo, Brazil)2018
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.
Synthesis in Clinics (Sao Paulo, Brazil), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global herpes zoster burden in adults with COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Association of COPD exacerbations and acute cardiovascular events: a systematic review and meta-analysis.Therapeutic advances in respiratory diseasePooled it
- Explainable multi-modal approach for uncovering key predictors of stroke-risk from ECG, EMG, blood pressure, and respiratory signals.Scientific reports · 2026Article
- Association of cataract surgery with stroke among older adults in the United States.Eye (London, England) · 2025Article
- Frequency of Stroke in Patients With Chronic Obstructive Pulmonary Disease: A Retrospective Study.Cureus · 2025Article
- The Risk of Ischemic Stroke in Patients with Chronic Obstructive Pulmonary Disease and Atrial Fibrillation.Life (Basel, Switzerland) · 2025Article
- Comorbidities and Cause of Death in COPD Patients Compared to Non-COPD Controls: An 8-year Observational Retrospective Healthcare Claims Database Cohort Study.International journal of chronic obstructive pulmonary disease · 2025Observational
- Prediction of postoperative stroke in patients experienced coronary artery bypass grafting surgery: a machine learning approach.Frontiers in cardiovascular medicine · 2024Article
- Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease-induced neuropathological comorbidities.British journal of pharmacology · 2024Review
- Impact of Preexisting Alcohol Use Disorder, Bipolar Disorder, and Schizophrenia on Ischemic Stroke Risk and Severity: A Lebanese Case-Control Study.Healthcare (Basel, Switzerland) · 2023Article
- Eating Behaviors, Lifestyle, and Ischemic Stroke: A Lebanese Case-Control Study.International journal of environmental research and public health · 2023Review
- Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation.Open medicine (Warsaw, Poland) · 2023Article
- Underestimated Ischemic Heart Disease in Major Adverse Cardiovascular Events after Septicemia Discharge.Medicina (Kaunas, Lithuania) · 2022Article
- Investigation of Flow Changes in Intracranial Vascular Disease Models Constructed with MRA Images.Sensors (Basel, Switzerland) · 2022Article
- New-Onset Atrial Fibrillation Is a Risk Factor of Ischemic Stroke in Chronic Obstructive Pulmonary Disease.Healthcare (Basel, Switzerland) · 2022Article
- The effects of medications for treating COPD and allied conditions on stroke: a population-based cohort study.NPJ primary care respiratory medicine · 2022Article
- Post-Stroke Outcomes of Patients with Chronic Obstructive Pulmonary Disease.Brain sciences · 2022Article
- HATInternational journal of medical sciences · 2022Article
- Influenza Vaccination and Risk of Stroke in Women With Chronic Obstructive Pulmonary Disease: A Nationwide, Population-Based, Propensity-Matched Cohort Study.Frontiers in medicine · 2022Article
- Novel Technique to Measure Pulse Wave Velocity in Brain Vessels Using a Fast Simultaneous Multi-Slice Excitation Magnetic Resonance Sequence.Sensors (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased stroke risk among chronic obstructive pulmonary disease patients has not yet been established. In this study, we conducted a systematic review and meta-analysis to assess stroke risk among chronic obstructive pulmonary disease patients. PubMed, EMBASE, and the Cochrane Library were systematically searched from database inception until December 31, 2016 to identify longitudinal observational studies that investigated the association between chronic obstructive pulmonary disease and stroke. Stroke risk was quantified by overall and subgroup analyses, and a pooled hazard ratio was calculated. Study quality was evaluated using the Newcastle-Ottawa Scale. Publication bias was assessed using Begg's rank correlation test. Eight studies met the inclusion criteria. In a random-effects model, significantly increased stroke risk was observed among chronic obstructive pulmonary disease patients (hazard ratio, 1.30; 95% confidence interval, 1.18-1.43). In subgroup analyses stratified by stroke subtype, study quality, and adjustment by socioeconomic status, the association between increased stroke risk and chronic obstructive pulmonary disease patients was robust. Statistically significant publication bias was not detected. In summary, chronic obstructive pulmonary disease was found to be associated with increased stroke risk. Additional prospective studies are required to elucidate the mechanisms underlying the increase in stroke risk and identify effective preventive interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.